IVF outcome in women with endometriosis in relation to tumour necrosis factor and anti-Müllerian hormone

H Falconer, Falconer H, Henrik Falconer, J Sundqvist, Jonas Sundqvist, Sundqvist J, Kristina Gemzell‐Danielsson, Gemzell-Danielsson K, K Gemzell-Danielsson, von Schoultz B, B von Schoultz, Bo von Schoultz, D'Hooghe TM, T M D'Hooghe, TM D'Hooghe, Gerald M. Fried, Fried G, G Fried
Reproductive BioMedicine Online · 2009 · vol. 18(4) , pp. 582–588 · doi:10.1016/s1472-6483(10)60138-1 · PMID:19401003 · W2117199981
Observational OA: bronze CC0 ⤵ 45 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated the relationship between IVF outcomes and levels of tumor necrosis factor and anti-Müllerian hormone in women with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

This study reports on anti-Müllerian hormone (AMH) in serum and follicular fluid (FF) in relation to inflammatory parameters in women with and without endometriosis undergoing IVF. Serum and FF samples were obtained from 72 women, with (n = 34) and without (n = 38) endometriosis, undergoing IVF. The concentrations of AMH, FSH, tumour necrosis factor (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF) and several interleukins were analysed. Women with endometriosis had significantly lower AMH in serum and FF (serum: 6.38 versus 12.8 pM; P < 0.01, FF: 14.0 versus 19.6 pM; P < 0.05). TNF was increased in FF (40.0 versus 30.8 pg/ml, P < 0.05) from women with endometriosis and significantly higher concentrations of IL-15 and GM-CSF were detected in FF (both P < 0.05). During IVF, women with endometriosis responded well to FSH but had lower fertilization rates. Women with endometriosis have elevated concentrations of several cytokines in FF. They respond adequately to exogenous FSH but may have impaired oocyte quality, reflected in lower fertilization rates, presumably resulting from an inflammatory process in the ovaries. Further studies are needed to elucidate the role of AMH in predicting ovarian reserve in women with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Fertilization in Vitro Follicular Fluid Adult Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Anti-Mullerian Hormone Anti-Mullerian Hormone Cytokines Cytokines Cytokines Endometriosis Endometriosis Female Female Fertilization in Vitro Fertilization in Vitro Follicle Stimulating Hormone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (47)

Cited by (46)

Source provenance

europepmc
last seen: 2026-10-09T06:09:53.026058+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:06:23.467768+00:00
License: CC0 · commercial use OK