The Effect of Unilateral Endometrioma Excision on Ovarian Reserve
Laparoscopic endometrioma excision significantly reduced antral follicle count in the operated ovary compared to the contralateral ovary, indicating a potential negative impact on ovarian reserve.
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This prospective, observational, operated versus non-operated site comparative study evaluated 21 women aged 20–36 with unilateral ovarian endometriomas (>30 mm) who underwent laparoscopic ovarian tissue-sparing stripping cystectomy, with ovarian reserve assessed at the third postoperative month using antral follicle counts (AFC) and blood FSH. AFCs on days 2–5 of the third postoperative follicular phase were measured by independent blinded examiners and compared between operated and non-operated ovaries; pre- and postoperative FSH were also compared. The operated side had significantly fewer AFCs than the non-operated side (2.61±1.24 vs 4.23±0.88), while FSH showed a statistically significant but reportedly clinically non-significant difference (6.7±1.8 vs 6.9±1.6), and no correlation was found between AFC and postoperative FSH. The study is limited by its small sample size and short follow-up focusing on AFC/FSH rather than longer-term fertility outcomes. This paper is centrally about endometriosis—specifically how unilateral laparoscopic endometrioma excision via stripping affects ovarian reserve markers.
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