Dysregulation of Angiogenesis and Inflammatory Genes in Endometrial Mesenchymal Stem Cells and Their Contribution to Endometriosis

Shermineh Heydari, Ladan Kashani, Mehrdad Noruzinia
Iranian journal of allergy, asthma, and immunology · 2021 · vol. 20(6) , pp. 740–750 · doi:10.18502/ijaai.v20i6.8025 · PMID:34920657 · W3200895534
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Endometrial mesenchymal stem cells from endometriosis patients showed up-regulated expression of angiogenesis and inflammatory genes, with co-expressed genes enriched in cytokine signaling pathways.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

The paper investigates dysregulation of angiogenesis and inflammatory genes in endometrial mesenchymal stem cells and examines how these gene expression changes may contribute to endometriosis. It focuses on the gene-level alterations in these cells using a study design aimed at linking mesenchymal stem cell molecular behavior to disease-relevant pathways, with the key finding being that angiogenesis- and inflammation-related gene dysregulation occurs in this cellular context. A limitation explicitly acknowledged is not provided in the provided text excerpt, so study constraints cannot be determined from the available information. This paper is centrally about endometriosis — it specifically examines dysregulated angiogenesis and inflammatory genes in endometrial mesenchymal stem cells as contributing mechanisms.

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Abstract

Endometriosis is a common, chronic, inflammatory disorder in women, characterized by the presence of endometrial tissue outside the uterus cavity. The disease affects ~10% of women during their reproductive age. There is some debates on the pathogenesis of endometriosis and its mechanism among the scientists; therefore, different hypotheses have been suggested. According to Sampson theory, a possible mechanism for seeding ectopic endometriotic lesions is a dysregulation of endometrial mesenchymal stem cells (eMSCs). In the present study, we evaluated the expression of candidate genes in eMSCs obtained from endometriosis patients and compared them with non-endometriosis female patients. In addition, a bioinformatic analysis was conducted to uncover the genes in the list of our co-expression gene network in endometriosis. According to our results, the expression of vascular endothelial growth factor A, C-X-C-motif chemokine ligand 8, interleukin-6, and intercellular adhesion molecule-1 genes were up-regulated in the eMSCs isolated from endometriosis patients. There was no significant difference in the expression of the LaminB1 gene between the endometriosis and non-endometriosis patients. On the other hand, our bioinformatics analysis demonstrated that co-expressed genes were enriched in the cytokine signalling pathway. Our study provides valuable insights into the gene expression dysregulation in eMSCs derived from endometriosis patients and suggests a possible function for co-expressed networks in the pathogenesis of endometriosis. To confirm the results, more investigations are required.
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Publication Iranian Journal of Allergy, Asthma and Immunology Record type Journal article Published 12 December 2021 Authors Shermineh Heydari | Ladan Kashani | Mehrdad Noruzinia The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijaai.v20i6.8025', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'Iranian Journal of Allergy, Asthma and Immunology', 'primary-resource': 'http://publish.kne-publishing.com/index.php/IJAAI/article/view/8025', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3119', 'tld': 'tums.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://publish.kne-publishing.com/index.php/IJAAI/article/view/8025', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '12 December 2021', 'publication': 'Iranian Journal of Allergy, Asthma and Immunology', 'title': 'Dysregulation of Angiogenesis and Inflammatory Genes in Endometrial Mesenchymal Stem Cells and Their Contribution to Endometriosis', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijaai.v20i6.8025', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Shermineh Heydari | Ladan Kashani | Mehrdad Noruzinia', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijaai.v20i6.8025 JSON XML

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gene Expression Gene Expression Regulation Inflammation Mesenchymal Stem Cells Neovascularization, Pathologic Adult Case-Control Studies Computational Biology Endometriosis Female Gene Regulatory Networks Genetic Markers Humans Inflammation Neovascularization, Pathologic

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