Editorial: Endometriosis: pathogenesis, diagnosis and treatment, volume II

Simone Ferrero, Mainak Dutta
Frontiers in endocrinology · 2023 · vol. 14 , pp. 1334596 · doi:10.3389/fendo.2023.1334596 · PMID:38179302 · PMC10765597 · W4389866812
editorial OA: gold CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This editorial introduces the second volume on endometriosis, covering its pathogenesis, diagnosis, and treatment, building upon previous research.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This editorial describes current knowledge on endometriosis pathogenesis, diagnosis, and treatment, highlighting studies included in the Research Topic that investigate estrogen metabolism, hypoxia-related unfolded protein response, cytokine-associated symptom pathways, genetic and epigenetic dysregulation, and the microbiome’s role in inflammatory processes, alongside data on ovarian reserve and reproductive outcomes. It summarizes the diagnostic challenge that laparoscopy with histology remains the gold standard and notes the lack of reliable non-invasive biomarkers. Key reported findings across included studies include associations between specific estradiol metabolites and risk/symptoms, identification of differentially expressed genes implicating TLR4/NF-κB and Wnt/frizzled signaling, and extensive differentially methylated loci in eutopic versus ectopic tissues, but the editorial does not provide a unified meta-analysis and is limited by the heterogeneity of included studies. This paper is centrally about endometriosis — an editorial overview of pathogenesis, diagnosis, and treatment research, synthesizing multiple mechanistic and translational findings.

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Abstract

EDITORIAL article Front. Endocrinol., 18 December 2023Sec. Reproduction Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1334596
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Author

SF: Writing – original draft. MD: Writing – review & editing.

Funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.

Conflict

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Epigenesis, Genetic Epigenesis, Genetic Epigenesis, Genetic Epigenesis, Genetic Epigenesis, Genetic Epigenesis, Genetic Epigenesis, Genetic Female Female Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (6)

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