Exploring the link between serum uric acid and endometriosis: a cross-sectional analysis utilizing NHANES data from 1999-2006

Haiwei Chen, Honglei Chen, Yuling Chen, Xiaotong Chen, Lixin Tang, Jiaqi Liu, Wen-Jing Shi, Wenjing Shi, Yong-jun Ou, Yu-Hua Ou
Frontiers in endocrinology · 2025 · vol. 16 , pp. 1536300 · doi:10.3389/fendo.2025.1536300 · PMID:40303639 · PMC12037370 · W4409469115
article OA: gold CC0
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This cross-sectional analysis of NHANES data found a positive association between higher serum uric acid levels and an increased risk of endometriosis in women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This cross-sectional study analyzed NHANES data from 1999–2006, including 5,162 women aged 20–54 years, to assess whether continuous serum uric acid levels and quartiles were associated with self-reported, provider-diagnosed endometriosis using weighted multivariable logistic regression with subgroup analyses and smooth curve fitting. The authors found a positive association between serum uric acid and endometriosis risk (OR 1.25, 95% CI 1.09–1.44; P = 0.003), with women in the highest uric acid quartile having substantially higher odds compared with the lowest quartile (OR 2.33, 95% CI 1.28–4.23; P = 0.009), and a linear positive pattern across the uric acid range, with no subgroup heterogeneity. The paper’s main limitation is that endometriosis status is based on self-report and the design is cross-sectional, which prevents establishing temporality. This paper is centrally about endometriosis—specifically the association between serum uric acid levels and the prevalence of endometriosis in women using NHANES data.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Background: Substantial impacts on the female reproductive system have been definitively linked to heightened levels of serum uric acid. However, evidence directly linking increased serum uric acid levels to endometriosis in women remains sparse, and the precise characteristics of this influence are still not fully understood. Objective: To explore the exact relationship between serum uric acid and endometriosis. Study design: Referencing the data accumulated from the National Health and Nutrition Examination Survey (NHANES), this study covers the period from 1999 to 2006, conducted an analysis of 5,162 female participants aged 20 to 54 years (representing a sample size of approximately 66,927,890 women). The study adopted a cross-sectional methodology to delve into the tie between serum uric acid and the prevalence of endometriosis. Utilizing rigorous methodologies, including weighted multivariable logistic regression models, subgroup analyses, and statistical methodologies for smooth curve fitting. Results: A positive association was found between continuous serum uric acid and the risk of endometriosis (OR = 1.25, 95% CI [1.09, 1.44], P = 0.003). At the same time, women in the highest quartile had a 133% higher risk of endometriosis compared with women with the lowest quartile of uric acid (OR=2.33,95%CI [1.28, 4.23], P=0.009). At the same time, smooth curve fitting also found a linear positive correlation between serum uric acid and endometriosis. There was no heterogeneity in subgroup analysis. Conclusion: The study indicates a strong link between increased serum uric acid levels and the appearance of endometriosis in women. Specifically, women with elevated uric acid levels face a higher likelihood of developing endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (65)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pmc
last seen: 2026-05-13T20:22:03.195721+00:00
pubmed
last seen: 2026-05-30T00:31:42.381584+00:00
License: CC0 · commercial use OK