Analysis of the ectoenzymes ADA, ALP, ENPP1, and ENPP3, in the contents of ovarian endometriomas as candidate biomarkers of endometriosis

Carla Trapero, Lluís Jover, Lluis Jover, Maria Eulàlia Fernández-Montolí, Maria-Eulalia Fernández-Montolí, Amparo García-Tejedor, Amparo García‐Tejedor, August Vidal, Inmaculada Gómez de Aranda, Jordi Ponce, Xavier Matias-Guiu, Xavier Matías‐Guiu, Mireia Martín‐Satué
American journal of reproductive immunology (New York, N.Y. : 1989) · 2017 · vol. 79(2) · doi:10.1111/aji.12794 · PMID:29194839 · W2771168619
article OA: closed CC0 ⤵ 8 in-corpus citations
View on OpenAlex View on PubMed View at publisher

Abstract

PROBLEM: The diagnosis of endometriosis, a prevalent chronic disease with a strong inflammatory component, is usually delayed due to the lack of noninvasive diagnostic tests. Purinergic signaling, a key cell pathway, is altered in many inflammatory disorders. The aim of the present work was to evaluate the levels of adenosine deaminase (ADA), alkaline phosphatase (ALP), ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), and ENPP3, elements of purinergic signaling, as biomarker candidates for endometriosis. METHOD OF STUDY: A case-control comparative study was conducted to determine ADA, ALP, ENPP1 and ENPP3 levels in echo-guided aspirated fluids of endometriomas (case group) and simple ovarian cysts (control group) using the ELISA technique. RESULTS: Adenosine deaminase, ALP, ENPP1, and ENPP3 were present and quantifiable in the contents of endometriomas and simple cysts. There were significant differences in ADA and ENPP1 levels in endometriomas in comparison with simple cysts (2787 U/L and 103.9 ng/mL more in endometriomas, for ADA and ENPP1, respectively). Comparisons of ALP and ENPP3 levels between the two groups did not reveal significant differences. CONCLUSION: The ectoenzymes ADA and ENPP1 are biomarker candidates for endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Adenosine Deaminase Endometriosis Ovarian Cysts Ovary Phosphoric Diester Hydrolases Pyrophosphatases Adenosine Deaminase Adolescent Adult Aged Aged, 80 and over Alkaline Phosphatase Alkaline Phosphatase Biomarkers Biomarkers Biopsy, Needle Case-Control Studies Endometriosis Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (8)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:07.505861+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK