POLYMORPHISMS OF THE PROGESTERONE RECEPTOR GENE IN ENDOMETRIOSIS PATIENTS OF SOUTH SUMATRA, INDONESIA

Muhammad Irsan Saleh, Rizki Andini Nawawi, Subandrate Subandrate
In: Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya · 2022 · vol. 9(2) , pp. 213–218 · doi:10.32539/jkk.v9i2.17508 · W4229369726
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This study identified the +331G/A progesterone receptor gene polymorphism in 42 endometriosis patients from Palembang, South Sumatra, with a 61.9% heterozygous mutant genotype frequency.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-31 · read from full text ⓘ

This study investigated the presence of the +331G/A polymorphism in the progesterone receptor gene among endometriosis patients residing in Palembang, South Sumatra. Researchers analyzed tissue samples from 42 individuals using polymerase chain reaction and restriction fragment length polymorphism techniques to identify specific genetic variants. The results indicated that 61.9 percent of the subjects carried the heterozygous mutant genotype, with an overall polymorphic allele frequency of 30.9 percent, while no homozygous mutant cases were observed. This paper is centrally about endometriosis — specifically examining the association between progesterone receptor gene polymorphisms and the condition in a specific Indonesian population.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Polymorphisms of the progesterone receptor gene alter the expressions of two receptor isoforms involved in the regulation of progesterone's antiproliferative effect in endometriotic tissue. This study aims to identify the +331G/A polymorphism of the progesterone receptor gene in endometriosis patients in Palembang, South Sumatra. Identification of +331G/A single-nucleotide polymorphism (SNP) was conducted on 42 endometriosis patients through polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). In this study, twenty-six (61.9%) subjects had heterozygous mutant genotype for the +331G/A SNP. No subject with homozygous mutant genotype for the +331G/A polymorphism was identified. The frequencies of polymorphic alleles for the +331G/A polymorphism was 30.9%. In conclusion, the +331G/A progesterone receptor gene polymorphism was present in endometriosis patients in Palembang, South Sumatra. This finding may warrant further studies to determine whether this polymorphism play a role in the development of endometriosis in the Indonesian population.
Full text 1,269 characters · extracted from oa-doi-fallback · click to expand
Polymorphisms of the Progesterone Receptor Gene in Endometriosis Patients of South Sumatra, Indonesia Main Article Content Keywords: endometriosis, gen reseptor progesterone, polimorfisme, 331G/AAbstract Polimorfisme pada gen reseptor progesteron dapat mengubah ekspresi dua isoform reseptor progesteron, yang terlibat dalam regulasi efek antiproliferatif progesteron di jaringan endometriotik. Studi ini bertujuan mengidentifikasi polimorfisme +331G/A gen reseptor progesteron pada pasien endometriosis di Palembang, Sumatera Selatan. Identifikasi single-nucleotide polymorphism (SNP) +331G/A dilakukan pada 42 pasien endometriosis dengan menggunakan polymerase chain reaction (PCR) dan restriction fragment length polymorphism (RFLP). Pada penelitian ini, didapatkan 26 subjek (61,9%) memiliki genotip heterozigot mutan terhadap SNP +331G/A. Tidak ditemukan subjek dengan genotip homozigot mutan terhadap SNP +331G/A. Frekuensi alel polimorfik SNP +331G/A didapatkan sebesar 30,9%. Dapat disimpulkan bahwa polimorfisme +331G/A gen reseptor progesteron teridentifikasi pada pasien endometriosis di Palembang, Sumatera Selatan. Penelitian selanjutnya diperlukan guna menentukan peran polimorfisme ini dalam patogenesis endometriosis, khususnya pada pasien di Indonesia.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

References (6)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK