Progesterone Resistance in Endometriosis: an Acquired Property?

Brett McKinnon; Michael D. Mueller; Michael Mueller; Mueller M; Montgomery G; Grant W. Montgomery; Grant Montgomery

doi:10.1016/j.tem.2018.05.006

Progesterone Resistance in Endometriosis: an Acquired Property?

Brett McKinnon, Michael D. Mueller, Michael Mueller, Mueller M, Montgomery G, Grant W. Montgomery, Grant Montgomery

Trends in endocrinology and metabolism: TEM · 2018 · vol. 29(8) , pp. 535–548 · doi:10.1016/j.tem.2018.05.006 · PMID:29934050 · W2808923566

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This study investigates whether progesterone resistance in endometriosis is an acquired characteristic rather than an intrinsic one.

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Abstract

Endometriosis is the growth of endometrial tissue outside the uterus and is characterized by progesterone resistance and changes in global and progesterone target gene expression. However, the mechanism behind this and whether it is innate, acquired, or present in both the eutopic and ectopic tissue in not always clear. We find large-scale gene expression studies in eutopic tissue, indicative of progesterone resistance, are often contradictory, potentially due to the dynamic nature of this tissue, whereas suppressed progesterone receptor expression is supported in ectopic but not eutopic tissue. This suggests more studies are required in eutopic tissue particularly, and that potentially the suppressed progesterone receptor (PR) expression is a consequence of the pathogenic process and exposure to the peritoneal environment.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Endometrium Gene Expression Gene Expression Receptors, Progesterone Uterine Diseases Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Receptors, Progesterone Receptors, Progesterone Uterine Diseases Uterine Diseases

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References (100)

Cited by (50)

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[1] Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis via openalex

[2] Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis via openalex

[3] Aberrant integrin expression in the endometrium of women with endometriosis via openalex

[4] Aberrant integrin expression in the endometrium of women with endometriosis via openalex

[5] Abnormal Pathways in Endometriosis in Relation to Progesterone Resistance: A Review via openalex

[6] Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants via openalex

[7] Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis via openalex

[8] Altered expression of progesterone receptor isoforms A and B in human eutopic endometrium in endometriosis patients via openalex

[9] Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification via openalex

[10] Aromatase expression in endometriotic tissues and cell cultures of patients with endometriosis via openalex

[11] Association between polymorphisms in the progesterone receptor gene and endometriosis via openalex

[12] Chemokine bioactivity of RANTES in endometriotic and normal endometrial stromal cells and peritoneal fluid via openalex

[13] Combined mRNA microarray and proteomic analysis of eutopic endometrium of women with and without endometriosis via openalex

[14] Contribution of bone marrow-derived stem cells to endometrium and endometriosis via openalex

[15] Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization via openalex

[16] Deficiency of immunophilin FKBP52 promotes endometriosis via openalex

[17] Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol via openalex

[18] Differential expression of genes in eutopic and ectopic endometrium from patients with ovarian endometriosis via openalex

[19] Differential regulation of Akt phosphorylation in endometriosis via openalex

[20] DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection via openalex

[21] DNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection via openalex

[22] Dominant expression of progesterone receptor form B mRNA in ovarian endometriosis via openalex

[23] Dose-response effect of interleukin (IL)-1β, tumour necrosis factor (TNF)-α, and interferon-γ on the in vitro production of epithelial neutrophil activating peptide-78 (ENA-78), IL-8, and IL-6 by human endometrial stromal cells via openalex

[24] Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why via openalex

[25] Endometrial stromal progesterone receptor-A/progesterone receptor-B ratio: no difference between women with and without endometriosis via openalex

[26] Enhanced inflammatory activity of endometriotic lesions from the rectovaginal septum via openalex

[27] Estrogen and progesterone receptors in endometriotic tissue and endometrium: comparison according to localization and recurrence via openalex

[28] Estrogen and progesterone receptors in endometriotic tissue and endometrium: comparison according to localization and recurrence via openalex

[29] Estrogen biosynthesis and signaling in endometriosis via openalex

[30] Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women via openalex

[31] Evaluation of endometrial inflammation by quantification of macrophages, T lymphocytes, and interleukin-1 and -6 in human endometrium via openalex

[32] Expression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 genes in eutopic endometrium of infertile women with endometriosis during the implantation window: a pilot study via openalex

[33] Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility via openalex

[34] Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis via openalex

[35] Genetics of endometriosis: a role for the progesterone receptor gene polymorphism PROGINS? via openalex

[36] Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes via openalex

[37] Global gene analysis of late secretory phase, eutopic endometrium does not provide the basis for a minimally invasive test of endometriosis via openalex

[38] hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells via openalex

[39] Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis via openalex

[40] History of endometriosis may adversely affect the outcome in menopausal recipients of sibling oocytes via openalex

[41] Hormonal contraceptive use and the prevalence of endometriotic lesions at different regions within the peritoneal cavity via openalex

[42] Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis via openalex

[43] Immunohistochemical analysis of oestrogen and progesterone receptors in endometriotic tissue and endometrium via openalex

[44] Immunolocalization and regulation of the chemokine RANTES in human endometrial and endometriosis tissues and cells via openalex

[45] Immunolocalization and Regulation of the Chemokine RANTES in Human Endometrial and Endometriosis Tissues and Cells via openalex

[46] Inflammation influences steroid hormone receptors targeted by progestins in endometrial stromal cells from women with endometriosis via openalex

[47] Inflammatory status influences aromatase and steroid receptor expression in endometriosis via openalex

[48] Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study via openalex

[49] Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics via openalex

[50] MicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12 via openalex

[51] MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis via openalex

[52] Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex

[53] Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis via openalex

[54] Ovarian steroid receptor expression in endometriosis and in two potential parent epithelia: endometrium and peritoneal mesothelium via openalex

[55] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[56] Peritoneal Endometriosis, Due to the Menstrual Dissemination of Endometrial Tissue into the Peritoneal Cavity via openalex

[57] Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities via openalex

[58] Presurgical management of dysmenorrhea and endometriosis in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome via openalex

[59] Progesterone receptor isoform A but not B is expressed in endometriosis via openalex

[60] Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosis via openalex

[61] Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4 via openalex

[62] Progesterone resistance in endometriosis: origins, consequences and interventions via openalex

[63] PROGINS receptor gene polymorphism is associated with endometriosis via openalex

[64] Prolonged stimulation with tumor necrosis factor-alpha induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells via openalex

[65] Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis via openalex

[66] Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis via openalex

[67] Regulated on activation, normal T-cell-expressed and -secreted mRNA expression in normal endometrium and endometriotic implants: assessment of autocrine/paracrine regulation by in situ hybridization via openalex

[68] Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells via openalex

[69] Retrograde menstruation in healthy women and in patients with endometriosis via openalex

[70] Steroidal regulation of endometriosis tissue: lack of induction of 17 beta-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol via openalex

[71] Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis via openalex

[72] Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity via openalex

[73] Surgery for bladder endometriosis: long-term results and concomitant management of associated posterior deep lesions via openalex

[74] The altered distribution of the steroid hormone receptors and the chaperone immunophilin FKBP52 in a baboon model of endometriosis is associated with progesterone resistance during the window of uterine receptivity via openalex

[75] The association between progestins, nuclear receptors expression and inflammation in endometrial stromal cells from women with endometriosis via openalex

[76] The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase via openalex

[77] The peritoneum is both a source and target of TGF-β in women with endometriosis via openalex

[78] The role of microRNAs in endometriosis and associated reproductive conditions via openalex

[79] The role of the lymphatic system in endometriosis: a comprehensive review of the literature via openalex

[80] TNFα-induced IKKβ complex activation influences epithelial, but not stromal cell survival in endometriosis via openalex

[81] Transcriptional characterizations of differences between eutopic and ectopic endometrium via openalex

[82] Unexplained infertility patients present the mostly impaired levels of progesterone receptors: Prospective observational study via openalex

[83] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis via openalex

[84] Uterine natural killer cell progenitor populations predict successful implantation in women with endometriosis-associated infertility via openalex

[85] Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium via openalex

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