MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in endometriosis — review of literature

Tomasz Szaflik, Hanna Romanowicz, Krzysztof Szyllo, Krzysztof Szyłło, Beata Smolarz
Ginekologia polska · 2023 · vol. 94(12) , pp. 997–1003 · doi:10.5603/gpl.95968 · PMID:37602417 · W4386019292
review OA: gold CC0 ⤵ 2 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review summarizes recent findings on the role of microRNAs and long non-coding RNAs in endometriosis pathogenesis and their potential for early genetic diagnosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This review summarizes evidence that microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) may contribute to endometriosis pathogenesis and serve as non-invasive biomarkers. It describes miRNA biogenesis and regulation, then reports that altered miRNA profiles occur in eutopic and ectopic endometrium (including changes in let-7b, miR-449b3p, miR-139-5p, miR-375, and miRNAs linked to mTOR/VEGF and other pathways affecting inflammation, angiogenesis, proliferation, and tissue remodeling), with plasma miRNA panels proposed to distinguish endometriosis from controls in moderate cohorts. A key limitation emphasized is that biomarker utility requires large, well-designed cohort studies and detailed analyses, and that miRNA diagnostic applications remain early-stage, alongside a need to further clarify upstream genetic/epigenetic drivers. This paper is centrally about endometriosis — it focuses specifically on how miRNAs and lncRNAs may underlie endometriosis biology and biomarker development.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a disease of the female genital organs, the causes of which are not fully understood. Recent studies have shown that non-coding RNAs (ncRNAs) like long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) can contribute to the pathogenesis of endometriosis. Profiling of miRNA and lncRNA expression is carried out using state-of-the-art molecular biology techniques (RT-PCR, sequencing, microarray analysis). The use of the latest technologies may make it possible to establish a genetic profile, which is a promising prospect for early diagnosis of endometriosis. In the future, genetic testing may become the gold diagnostic standard and eliminate invasive laparoscopy. In the case of endometriosis, it is important to extend the research to molecular aspects, which may facilitate the diagnosis of the disease or indicate new (based for example ncRNA) treatment methods. The paper presents the latest data on the importance of miRNA/lncRNA in endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (53)

Cited by (2)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-29T00:33:26.437191+00:00
License: CC0 · commercial use OK