Tata Laksana Terkini untuk Endometriosis

Tata Laksana Terkini untuk Endometriosis DOI: https://doi.org/10.56951/medicinus.v34i3.77Kata Kunci: endometriosis, infertilitas, tata laksana terkiniAbstrak Endometriosis merupakan penyakit ginekologi jinak yang sering dijumpai pada wanita usia produktif dengan insidensi sebesar 10%. Banyak teori mengenai terjadinya endometriosis, dan sampai saat ini, etiopatogenesis kondisi ini masih kontroversial. Memahami berbagai kemungkinan patogenesis endometriosis dapat menjadi dasar tata laksana kondisi ini. Manajemen terapi saat ini masih berdasarkan gejala utama yang dialami oleh wanita dengan endometriosis, berupa nyeri dan infertilitas. Sejumlah terapi telah dikembangkan berdasarkan patogenesis endometriosis, ditinjau dari aspek imunologi, angiogenik, hormonal, genetik, neurogenesis lokal, serta sensitisasi sentral, namun hingga saat ini terapi yang ideal dan bersifat kuratif untuk endometriosis masih belum didapatkan. Unduhan Referensi Bedaiwy MA, Alfaraj S, Yong P, Casper R. New developments in the medical treatment of endometriosis. Fertil Steril. 2017;107(3):555-65. DOI: https://doi.org/10.1016/j.fertnstert.2016.12.025 Berek JS, PJA H. Berek & Novak’s Gynecology 15th Ed. Wolters Kluwer Health; 2012. DOI: https://doi.org/10.1515/9783110287011.15 Caughey TLC& AB. Blueprints Obstetrics & Gynecology. Vol 148. 7th Ed. (Hauber M, ed.). Lippincott Williams & Wilkins, a Wolters Kluwer business; 2018. Speroff, Marc A. Fritz L. Clinical Gynecologic Endocrinology and Infertility. Vol 148. 8th Ed. Lipponcott Williams &Wilkins, a Wolters Kluwer business; 2011. Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Viganò P. Endometriosis. Nat Rev Dis Prim. 2018;4(1). DOI: https://doi.org/10.1038/s41572-018-0008-5 Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 2021;397(10276):839-52. DOI: https://doi.org/10.1016/S0140-6736(21)00389-5 Shafrir AL, Farland L V., Shah DK, et al. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018;51(July):1-15. DOI: https://doi.org/10.1016/j.bpobgyn.2018.06.001 Organization WH. Women of reproductive age (15-49 years) population (thousands). Published 2021. Available on URL https://www.who.int/data/maternal-newborn-child-adolescent-ageing/indicator-explorer-new/mca/women-of-reproductive-age-(15-49-years)-population-(thousands), cited Nov 2021. Ottolina J, Schimberni M, Makieva S, et al. Early-Life Factors, in-Utero Exposures and Endometriosis Risk: A Meta-Analysis. Reprod Biomed Online 2020;41(2):279-89. DOI: https://doi.org/10.1016/j.rbmo.2020.04.005 Parasar P, Ozcan P, Terry KL, Terry KL. Endometriosis : Epidemiology, Diagnosis and Clinical Management. Curr Obstet Gynecol Rep 2017;6(1):34-41. DOI: https://doi.org/10.1007/s13669-017-0187-1 Harris HR, Eke AC, Chavarro JE, Missmer SA. Fruit and vegetable consumption and risk of endometriosis. Hum Reprod. 2018;33(4):715-27. DOI: https://doi.org/10.1093/humrep/dey014 Chopra S. Endometriosis: An Enigma. (Chopra S, ed.). Taylor & Francis Group, LLC; 2020. DOI: https://doi.org/10.1201/9780429448980 Arafah M, Rashid S, Akhtar M. Endometriosis : A Comprehensive Review. Adv Anat Pathol. 2021;28(1):30-43. DOI: https://doi.org/10.1097/PAP.0000000000000288 Chantalat E, Valera MC, Vaysse C, et al. Estrogen receptors and endometriosis. Int J Mol Sci. 2020;21(8):1-17. DOI: https://doi.org/10.3390/ijms21082815 Johnson NP, Hummelshoj L, Adamson GD, et al. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod 2017;32(2):315-24. DOI: https://doi.org/10.1093/humrep/dew293 Andres MP, Borrelli GM, Abrão MS. Endometriosis classification according to pain symptoms: can the ASRM classification be improved? Best Pract Res Clin Obstet Gynaecol. 2018;51:111-8. DOI: https://doi.org/10.1016/j.bpobgyn.2018.06.003 Abrao MS, Andres MP, Miller CE, et al. AAGL 2021 Endometriosis Classification: An Anatomy-based Surgical Complexity Score. J Minim Invasive Gynecol. 2021;28(11):1941-50. DOI: https://doi.org/10.1016/j.jmig.2021.09.709 Carlyle D, Khader T, Lam D, Vadivelu N, Shiwlochan D, Yonghee C. Endometriosis Pain Management: a Review. Curr Pain Headache Rep. 2020;24(9). DOI: https://doi.org/10.1007/s11916-020-00884-6 Morotti M, Vincent K, Becker CM. Mechanisms of pain in endometriosis. Eur J Obstet Gynecol. 2016;209;3-8. DOI: https://doi.org/10.1016/j.ejogrb.2016.07.497 Chiantera V, Abesadze E, Mechsner S. How to understand the complexity of endometriosis-related pain. Journal of Endometriosis and Pelvic Pain Disorders 2017;9(1):30-8. DOI: https://doi.org/10.5301/je.5000271 Ronnett BM. Blaustein’s Pathology of the Female Genital Tract. European Society of Human Reproduction and Embryology. Guideline on the management of women with endometriosis. Available on URL https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Endometriosis-guideline.aspx cited Nov 2021. Supriyadi A, Haryadi D, Sauqi H, et al. Konsensus Tatalaksana Nyeri Endometriosis. Himpunan Endokrinologi Reproduksi dan Fertil Indones. Available on URL https://staff.ui.ac.id/system/files/users/kemal.harzif/publication/konsensus_endometriosis.pdf cited Nov 2021. Thomas A. Transvaginal sonography vs. clinical examination in the preoperative diagnosis of deep infiltrating endometriosis. Ultrasound Obstet Gynecol. 2011;37(4):480-7. DOI: https://doi.org/10.1002/uog.8935 Anastasiu CV, Moga MA, Neculau AE, et al. Biomarkers for the noninvasive diagnosis of endometriosis: State of the art and future perspectives. Int J Mol Sci. 2020;21(5):1-24. DOI: https://doi.org/10.3390/ijms21051750 Tian Z, Chang XH, Zhao Y, Zhu HL. Current biomarkers for the detection of endometriosis. Chin Med J (Engl). 2020;133(19):2346-52. DOI: https://doi.org/10.1097/CM9.0000000000001063 Lee Y, Lee Y, Lee S, Jung S, Chon S. Correlation of preoperative biomarkers with severity of adhesion in endometriosis. J Gynecol Obstet Hum Reprod. 2020;49(1):101637. DOI: https://doi.org/10.1016/j.jogoh.2019.101637 Yeoman CJYHDDCMSRIM and IKOC. 乳鼠心肌提取 HHS Public Access. Physiol Behav. 2017;176(5):139-148. Cosar E, Mamillapalli R, Ersoy GS, Cho SY, Seifer B, Taylor HS. Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertil Steril. 2016;106(2):402-9. DOI: https://doi.org/10.1016/j.fertnstert.2016.04.013 Moustafa S, Burn M, Mamillapalli R, Nematian S, Flores V, Taylor HS. Accurate diagnosis of endometriosis using serum microRNAs. Am J Obstet Gynecol. 2020;223(4):557.e1-557.e11. DOI: https://doi.org/10.1016/j.ajog.2020.02.050 Schwartz K, Llarena NC, Rehmer JM, Richards EG, Falcone T. The role of pharmacotherapy in the treatment of endometriosis across the lifespan. Expert Opin Pharmacother. 2020;21(8):893-903. DOI: https://doi.org/10.1080/14656566.2020.1738386 Marjoribanks J, Ro A, Farquhar C, Proctor M. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea (Review). Cochrane Database Syst Rev 2015;2015(7):CD001751. DOI: https://doi.org/10.1002/14651858.CD001751.pub3 Vannuccini S, Clemenza S, Rossi M, Petraglia F. Hormonal treatments for endometriosis: The endocrine background. Rev Endocr Metab Disord. 2021;1-23. DOI: https://doi.org/10.1007/s11154-021-09666-w Saunders PTK, Horne AW. Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell 2021;184(11):2807-24. DOI: https://doi.org/10.1016/j.cell.2021.04.041 Brown J, Crawford TJ, Datta S, Prentice A. Oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev. 2018;2018(5).doi:10.1002/14651858.CD001019.pub3 DOI: https://doi.org/10.1002/14651858.CD001019.pub3 Zito G, Luppi S, Giolo E, et al. Medical Treatments for Endometriosis-Associated Pelvic Pain. Biomed Res Int 2014;2014:191967. DOI: https://doi.org/10.1155/2014/191967 Gezer A, Oral E. Progestin therapy in endometriosis. Women's Health 2016;11(5):643-52. DOI: https://doi.org/10.2217/whe.15.42 Diamond MP, Surrey E, Johnson NP, et al. Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist. N Engl J Med 2017;377:28-40. DOI: https://doi.org/10.1056/NEJMoa1700089 Surrey E, Taylor HS, Giudice L, et al. Long-Term Outcomes of Elagolix in Women With Endometriosis Results From Two Extension Studies. Obstet Gynecol 2018;132(1):147-60. DOI: https://doi.org/10.1097/AOG.0000000000002675 Of TAC, Gynecologists O and. Committee Opinion No.66: Aromatase Inhibitors in Gynecologic Practice. Obstet Gynecol 2016;127(6):e170-4. DOI: https://doi.org/10.1097/AOG.0000000000001484 Hong AR, Kim JH, Lee KH, et al. Long-term effect of aromatase inhibitors on bone microarchitecture and microarchitecture in non-osteoporotic postmenopausal women with breast cancer. Osteoporos Int. 2017;28(4):1413-22. DOI: https://doi.org/10.1007/s00198-016-3899-6 Tanbo T. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand. 2016;38(1):42-9. Lee D, Kim SK, Lee JR, Jee BC. Management of endometriosis-related infertility: Considerations and treatment options. Clin Exp Reprod Med. 2020;47(1):1-11. DOI: https://doi.org/10.5653/cerm.2019.02971 Ahmed TA, Ahmed SM, El-Gammal Z, et al. Oocyte aging: The role of cellular and environmental factors and impact on female fertility. Adv Exp Med Biol. 2020;1247:109-23. DOI: https://doi.org/10.1007/5584_2019_456 Song J, Duan C, Cai W, Wu W, Lv H, Xu J. Comparison of gnrh-a prolonged protocol and short gnrh-a long protocol in patients with thin endometrium for assisted reproduction: A retrospective cohort study. Drug Des Devel Ther. 2020;14:3673-82. DOI: https://doi.org/10.2147/DDDT.S270519 Cao X, Chang HY, Xu JY, et al. The effectiveness of different down-regulating protocols on in vitro fertilization-embryo transfer in endometriosis: A meta-analysis. Reprod Biol Endocrinol. 2020;18(16):1-12. DOI: https://doi.org/10.1186/s12958-020-00571-6 Blumenfeld Z. Fertility Preservation Using GnRH Agonists: Rationale, Possible Mechanisms, and Explanation of Controversy. Clin Med Insights Reprod Heal. 2019;13:1179558119870163. DOI: https://doi.org/10.1177/1179558119870163 National Institute for Health and Care Excellence. Endometriosis: diagnosis and management. Available on URL https://www.ncbi.nlm.nih.gov/books/NBK453273/ Cited Nov 2021. Osmanlıoğlu Ş, Şükür YE, Tokgöz VY, et al. Intrauterine insemination with ovarian stimulation is a successful step prior to assisted reproductive technology for couples with unexplained infertility. J Obstet Gynaecol (Lahore). 2021;0(0):1-6. Farquhar CM, Liu E, Armstrong S, Arroll N, Lensen S, Brown J. Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial. Lancet. 2018;391(10119):441-50. DOI: https://doi.org/10.1016/S0140-6736(17)32406-6 Kotlyar A, Taylor HS, D’Hooghe TM. Use of immunomodulators to treat endometriosis. Best Pract Res Clin Obstet Gynaecol. 2019;60:56-65 DOI: https://doi.org/10.1016/j.bpobgyn.2019.06.006 Agostinis C, Balduit A, Mangogna A, et al. Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target. Front Immunol. 2021;11:599117. DOI: https://doi.org/10.3389/fimmu.2020.599117 Carey ET, Till SR, As-Sanie S. Pharmacological Management of Chronic Pelvic Pain in Women. Drugs. 2017;77(3):285-301. DOI: https://doi.org/10.1007/s40265-016-0687-8 Hao M, Liu X, Rong P, Li S, Guo SW. Reduced vagal tone in women with endometriosis and auricular vagus nerve stimulation as a potential therapeutic approach. Sci Rep. 2021;11(1345):1-15. DOI: https://doi.org/10.1038/s41598-020-79750-9 Nagayasu M, Imanaka S, Kimura M, Maruyama S, Kobayashi H. Nonhormonal Treatment for Endometriosis Focusing on Redox Imbalance. Gynecol Obstet Invest. 2021;86(1-2):1-12. DOI: https://doi.org/10.1159/000512628 Unduhan Terbitan Bagian Diterbitkan Unduhan Lisensi Hak Cipta (c) 2021 Binarwan Halim, Timothy Adiwinata Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.