Diagnostic Accuracy of Urinary Cytokeratin 19 Fragment for Endometriosis

B A Lessey, Bruce A. Lessey, Ricardo Francalacci Savaris, R F Savaris, S Ali, Syed Waqas Ali, S Brophy, S Tomazic-Allen, Susan Tomazic-Allen, K Chwalisz, Kristof Chwalisż
Reproductive sciences (Thousand Oaks, Calif.) · 2014 · vol. 22(5) , pp. 551–555 · doi:10.1177/1933719114553064 · PMID:25296695 · W2113348991
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This study evaluated the diagnostic accuracy of urinary cytokeratin 19 fragment (CYFRA21-1) for detecting endometriosis.

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Abstract

Endometriosis affects up to 10% of women of reproductive age and 176 million women worldwide. The prevalence in women with infertility is between 30% and 50% but may be higher in women with pelvic pain, interstitial cystitis, or irritable bowel syndrome. Cytokeratin 19 has been suggested as a potential biomarker in urine for the diagnosis of this condition. The objective of this study was to prospectively determine the accuracy and the performance of a urinary cytokeratin 19 (uCYFRA 21-1) test for diagnosing endometriosis. Ninety-eight consecutive women who underwent laparoscopy had a urinary sample obtained before surgery and were included in the study. Endometriosis was diagnosed by laparoscopy and pathology in 64.3% (63 of 98 women). The estimates and 95% confidence intervals for sensitivity, specificity, positive and negative predictive values, and likelihood ratios were 11.1% (4.5%–21.5%), 94.3% (80.8%–99.3%), 77.7% (39.9–97.1), 37% (27–47.9), 1.94 (0.43–8.86), and 0.94 (0.84–1.06), respectively. Despite the high specificity, the uCYFRA 21-1 test has limited value for clinical practice to discriminate between women with and without endometriosis. Similar content being viewed by others

References

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Antigens, Neoplasm Endometriosis Endometriosis Keratin-19 Adult Antigens, Neoplasm Area Under Curve Biomarkers Biomarkers Endometriosis Endometriosis Female Humans Keratin-19 Laparoscopy Middle Aged Predictive Value of Tests Prospective Studies Reproducibility of Results ROC Curve

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