Omid Khorram

ORCID: 0000-0003-4996-5762 · 10 papers in corpus
2026
Transcriptomic and functional analysis of fibroid extracellular vesicles.
Clinical science (London, England : 1979) ·doi:10.1042/cs20250814

Exosomes were isolated from cultures of fibroid explants and matched myometrial explants, and their RNA cargo was analyzed by next-generation sequencing to profile both long and short RNA species. Fibroid-derived exosomes (Fib-EXO) expresse…

2025
Differential Expression of Small Non-Coding RNAs in Uterine Leiomyomas.
International journal of molecular sciences ·doi:10.3390/ijms26041688

We performed next-generation sequencing (NGS) on RNA from 19 paired leiomyoma (Lyo) and myometrium (Myo) specimens, stratified by race/ethnicity (White: n = 7; Black: n = 12) and mediator complex subunit 12 (MED12) mutation status (mutated:…

2024
The Functional Role of the Long Non-Coding RNA LINCMD1 in Leiomyoma Pathogenesis.
International journal of molecular sciences ·doi:10.3390/ijms252111539

Existing evidence indicates that LINCMD1 regulates muscle differentiation-related gene expression in skeletal muscle by acting as a miRNA sponge, though its role in leiomyoma development is still unknown. This study investigated LINCMD1's i…

2024
The immune landscape of uterine fibroids as determined by mass cytometry.
F&S science ·doi:10.1016/j.xfss.2024.06.004

ObjectiveTo study the differences in immune cell profiles in uterine fibroids (Fibs) and matched myometrium (Myo).DesignObservational study.SettingLaboratory study.Patient(s)The study included tissue that was collected from 10 pairs of Fib …

article 2022
Further characterization of tryptophan metabolism and its dysregulation in fibroids
·doi:10.1016/j.xfss.2022.04.005

OBJECTIVE: To determine the expression of enzymes in tryptophan (Trp) catabolism in fibroids and matched myometrium and determine the effects of race and mediator complex subunit 12 gene (MED12) mutation on their expression. DESIGN: Experim…

article 2002
Alterations in expression of endometrial endothelial nitric oxide synthase and αvβ3 integrin in women with endometriosis
Fertility and sterility ·doi:10.1016/s0015-0282(02)03347-2

ObjectiveTo determine the expression of endometrial endothelial nitric oxide synthase (eNOS) protein and alpha(v)beta(3) integrin in patients with and without endometriosis.DesignCase-control cohort study.SettingUniversity-based tertiary ca…

article 2001
Human uterine and ovarian expression of growth hormone–releasing hormone messenger RNA in benign and malignant gynecologic conditions
Fertility and sterility ·doi:10.1016/s0015-0282(00)01658-7

ObjectiveTo determine uterine and ovarian expression of growth hormone-releasing hormone (GHRH) messenger RNA (mRNA) in benign and pathologic gynecologic states.DesignCase-control study.SettingTertiary-care academic department.Patient(s)Wom…

article 2000
Altered Endometrial Expression of Endothelial Nitric Oxide Synthase (eNOS) in Women with Endometriosis
·doi:10.1016/s0015-0282(00)00782-2
article 2000
O-059 Altered Endometrial Expression of Endothelial Nitric Oxide Synthase

Objectives: Nitric oxide (NO) is a vasodilator synthesized from Larginine through the action of nitric oxide synthase (NOS). Recently we demonstrated that the endometrial expression of eNOS protein was higher during the secretory phase as c…

article 1993
Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis
American journal of obstetrics and gynecology ·doi:10.1016/0002-9378(93)90433-j

ObjectiveEndometriosis is a common gynecologic disorder in which the concentration and activation of peritoneal macrophages are increased. The goal of this study was to quantify pelvic fluid concentrations of two cytokines involved in macro…