The Holy Grail of endometriosis biomarkers in the diagnostic process – How much would it be worth and what does it look like?

Joanna Kacperczyk‐Bartnik, Natalia Żeber‐Lubecka, Stepan Feduniw, Paweł Bartnik, Marta Włodarczyk, Monika Abramiuk, Michał Ciebiera
In: Journal of Endometriosis and Pelvic Pain Disorders · 2023 · vol. 15(3-4) , pp. 109–115 · doi:10.1177/22840265231210903 · W4388500069
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review explores advances in non-invasive endometriosis diagnostics, focusing on molecular pathways and biomarkers, while critically analyzing current ESHRE guidelines that recommend against biomarker measurement due to insufficient evidence.

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Abstract

Previously, the gold standard for the diagnosis of endometriosis involved the performance of laparoscopic surgery, which allows the visualization and histological examination of the endometrial tissue. According to the latest guidelines published by the European Society of Human Reproduction and Embryology (ESHRE) in 2022, surgery is recommended only in patients with diagnostic difficulties associated with the use of non-invasive methods or in case of inappropriate or unsuccessful empirical treatment. At the same time, it is not recommended to use the measurement of biomarkers in the endometrial tissue, blood, menstrual or uterine fluids to diagnose endometriosis as the ESHRE guideline development group indicated the need of larger, multi-center prospective studies on this matter. The aim of this narrative review is to present advances in knowledge on non-invasive endometriosis diagnostic opportunities with emphasis on proteomics, the use of endometrial aspiration biopsy, iron metabolism, vitamin D-binding protein, extracellular matrix signaling pathways, epithelial−mesenchymal transformation, and other molecular pathways, together with a critical analysis of studies cited in the recent ESHRE guidelines.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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