Evaluation of the relationship between miR-337-3p and RAP1A gene in endometriosis

Mehran Dehghanian, Ghafour Yarahmadi, Javad Fazeli, Mohammad Yahya Vahidi Mehrjardi, Atiyeh Javaheri, Seyed Mehdi Kalantar, Mohammadreza Dehghani
In: Journal of Endometriosis and Pelvic Pain Disorders · 2022 · vol. 14(4) , pp. 178–182 · doi:10.1177/22840265221099622 · W4281693221
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that miR-337-3p expression was significantly decreased while RAP1A gene expression was significantly increased in endometriosis tissues compared to normal endometrium.

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Abstract

Background: Endometriosis, a prevalent multifactorial condition, has a different effect on mental and physical health in women. MicroRNAs have been reported as a main epigenetic factor in endometriosis pathogenesis. However, the role of miR-337-3p and its direct target gene, RAP1A, in endometriosis tissues have not been investigated. Objective: The aim of this study was to evaluate the expression level of miR-337-3p and RAP1A gene in endometriosis tissues and normal endometrium tissues. Materials and methods: We measured the expression levels of miR-337-3p and RAP1A gene by quantitative polymerase chain reaction (qRT-PCR) in 15 eutopic and ectopic tissue samples of superficial peritoneal lesions from women with endometriosis and 15 normal endometrial tissue samples from women without any symptom of endometriosis. Results: The results showed the expression level of RAP1A gene significantly increased in endometriosis tissue samples (both of ectopic and eutopic tissues), while miR-337-3p expression level decreased significantly in these tissues compared to the normal endometrium. Conclusion: In this study, we observed an inverse relationship between miR-337-3p and RAP1A gene expression in endometriosis. Dysregulation of these genes can also be interpreted as their role in the pathogenesis and progression of endometriosis.

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endometriosis

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