Expression of WT1 is down-regulated in eutopic endometrium obtained during the midsecretory phase from patients with endometriosis

Matsuzaki S, Sachiko Matsuzaki, Michel Canis, Claude Darcha, Darcha C, Pierre J Déchelotte, Pierre Déchelotte, Déchelotte PJ, Jean-Luc Pouly, Jean‐Luc Pouly, Pouly JL, G. Mage, Mage G, Gérard Mage
Fertility and sterility · 2006 · vol. 86(3) , pp. 554–558 · doi:10.1016/j.fertnstert.2006.02.101 · PMID:16879825 · W2079141105
article OA: closed CC0 ⤵ 13 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

WT1 expression was found to be reduced in the midsecretory phase endometrium of women diagnosed with endometriosis compared to healthy controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo investigate whether WT1 protein expression is altered in eutopic endometrium of endometriosis patients.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with endometriosis and fertile women with macroscopically normal pelvic cavities.Intervention(s)During surgery, endometrial tissues were obtained from 59 patients with deep infiltrating endometriosis, ovarian endometriosis, or only superficial peritoneal endometriosis. Control endometrial tissue samples were obtained from 40 fertile women who underwent laparoscopic tubal ligation or reversal of tubal sterilization.Main outcome measure(s)The percentage of nuclear surface positively immunostained for WT1 (PI) and WT1-positive microvessel density.Result(s)The PI was significantly lower in endometrial stromal cells from patients with deep infiltrating endometriosis than in stroma from control subjects during the midsecretory phase, whereas there was no significant difference between the two populations during the proliferative, early secretory, and late secretory phases. The PI was also significantly lower during the midsecretory phase in endometrial stromal cells from patients with ovarian endometriosis and superficial peritoneal endometriosis compared with control subjects.Conclusion(s)During the midsecretory phase, PI in endometrial stromal cells is down-regulated in patients with deep infiltrating endometriosis, ovarian endometriosis, and superficial peritoneal endometriosis compared with endometrium from healthy control subjects.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Luteal Phase Ovary WT1 Proteins Down-Regulation Endometriosis Endometrium Female Humans Luteal Phase Ovary WT1 Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (13)

Source provenance

europepmc
last seen: 2026-07-27T06:15:28.040536+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:12.369988+00:00
License: CC0 · commercial use OK