Expression of soluble adhesion molecules in sera of women with stage III and IV endometriosis
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This study investigated the levels of soluble adhesion molecules in the blood serum of women diagnosed with stage III and IV endometriosis.
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Abstract
ObjectiveTo determine the effect of stage III and IV endometriosis on serum concentration of soluble intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin.MethodsSera from women with laparoscopically proven stage III and IV endometriosis were analyzed for the presence of soluble ICAM-1, VCAM-1, and E-selectin using enzyme-linked immunosorbent assays. Concentrations of these molecules were compared with those of laparoscopically proven disease-free controls.ResultsWhen compared with controls, women with stage III and IV endometriosis had higher serum concentrations of soluble VCAM-1, lower serum concentration of soluble ICAM-1, and no difference in serum concentration of soluble E-selectin.ConclusionSignificant aberrations in levels of circulating adhesion molecules were found in women with stage III and IV endometriosis. These findings might shed light on the pathogenesis of endometriosis and be useful in the development of biochemical markers for disease stage.
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- Reduced frequency of perforin-positive CD8+ T cells in menstrual effluent of endometriosis patients compared to healthy controls 2020
- Endometriosis — insights into a multifaceted entity 2018
- Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture 2018
- Soluble VCAM-1/soluble ICAM-1 ratio is a promising biomarker for diagnosing endometriosis 2017
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Molecular aspects of endometriosis 2015
- Molecular aspects of development and regulation of endometriosis 2014
- Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis 2012
- Inflammation and Endometriosis 2011
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Effects of the levonorgestrel-releasing intrauterine system on cardiovascular risk markers in patients with endometriosis: a comparative study with the GnRH analogue 2009
- Efeitos do sistema intra-uterino de Levonorgestrel sobre marcadores de risco cardiovascular de pacientes com endometriose: estudo comparativo com o análogo do GnRH 2009
- The role of iron in the pathogenesis of endometriosis 2009
- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
- Serum and endometrial markers 2004
- Concentration of soluble intercellular adhesion molecule-1 in serum samples from patients with endometriosis collected during the luteal phase of the menstrual cycle 2003
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- last seen: 2026-06-10T17:14:06.276822+00:00
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