Peritoneal fluid environment in endometriosis. Clinicopathological implications

Bedaiwy MA, M A Bedaiwy, Mohamed A. Bedaiwy, Falcone T, T. Falcone, Tommaso Falcone
Minerva ginecologica · 2003 · vol. 55(4) , pp. 333–45 · PMID:14581858 · W2412560741
Review OA: closed CC0 ⤵ 65 in-corpus citations
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This review evaluates the complex role of peritoneal fluid, identified as a key inflammatory environment containing various active substances, in the etiopathogenesis of endometriosis and its associated complications.

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Abstract

Endometriosis is a puzzling disorder with obscure pathogenesis. The objective of this review was to evaluate the complex role of peritoneal fluid in the etiopathogenesis of endometriosis. Several studies suggest that peritoneal fluid is a key inflammatory environment associated with endometriosis. Many active substances (cytokines, growth factors, hormones and oxidative stress parameters) have been identified in endometriosis patients at different stages of the disease. Inflammatory mediators may be involved in the endometriosis associated-infertility and possibly pain. Furthermore, these mediators may represent a non surgical method for diagnosing endometriosis. Better understanding of the mechanism of cytokines, growth factor and reactive oxygen species production and detoxification and further investigation of their effects on the peritoneal fluid environment are essential to obtain new insight into this disease and eventually develop novel diagnostic and therapeutic remedies.

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Endometriosis Ascitic Fluid Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Immunologic Factors Immunologic Factors Immunologic Factors Infertility, Female Infertility, Female Infertility, Female Oxidative Stress

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

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