Nerve fibers and endometriotic lesions: partners in crime in inflicting pains in women with endometriosis

Dingmin Yan; Xishi Liu; Sun-Wei Guo; Sun‐Wei Guo

doi:10.1016/j.ejogrb.2016.06.017

Nerve fibers and endometriotic lesions: partners in crime in inflicting pains in women with endometriosis

Dingmin Yan, Xishi Liu, Sun-Wei Guo, Sun‐Wei Guo

European journal of obstetrics, gynecology, and reproductive biology · 2016 · vol. 209 , pp. 14–24 · doi:10.1016/j.ejogrb.2016.06.017 · PMID:27418559 · W2466134200

review OA: closed CC0 ⤵ 40 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This paper investigates the role of nerve fibers in endometriotic lesions and their contribution to pain experienced by women with endometriosis.

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Condition tags

mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Endometriosis Endometrium Nerve Fibers Pelvic Pain Quality of Life Sensory Receptor Cells Endometriosis Endometriosis Endometrium Female Humans Nerve Fibers Pelvic Pain Pelvic Pain Sensory Receptor Cells

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References (100)

Aberrant Expression of Leptin in Human Endometriotic Stromal Cells Is Induced by Elevated Levels of Hypoxia Inducible Factor-1α via openalex
A pilot study to evaluate the clinical relevance of endometriosis-associated nerve fibers in peritoneal endometriotic lesions via openalex
A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibers via openalex
Are endometrial nerve fibres unique to endometriosis? A prospective case–control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain via openalex
Aromatase and other steroidogenic genes in endometriosis: translational aspects via openalex
Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis via openalex
[Cannabinoid receptor 1 controls nerve growth in ectopic cyst in a rat endometriosis model]. via openalex
Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex
Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK/Erk1/2 signal pathway via openalex
Chronic pelvic pain: Cause, diagnosis and therapy from a gynaecologist's and an endoscopist's point of view via openalex
Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis via openalex
Comparative Study of the Neuropeptide-Y Sympathetic Nerves in Endometriotic Involved and Noninvolved Sacrouterine Ligaments in Women with Pelvic Endometriosis via openalex
Correlation between endometriosis-associated dysmenorrhea and the presence of typical or atypical lesions via openalex
Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications via openalex
Density of small diameter sensory nerve fibres in endometrium: a semi-invasive diagnostic test for minimal to mild endometriosis via openalex
Detection of Endometrial Nerve Fibres – a Novel Technique to Diagnose Endometriosis via openalex
Detection of the pan neuronal marker PGP9.5 by immuno-histochemistry and quantitative PCR in eutopic endometrium from women with and without endometriosis via openalex
Diagnosis of endometrial nerve fibers in women with endometriosis via openalex
Differences in uterine innervation at hysterectomy via openalex
Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis via openalex
Ectopic uterine tissue as a chronic pain generator via openalex
Effect of progestogens and combined oral contraceptives on nerve fibers in peritoneal endometriosis via openalex
Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis via openalex
Elevated Peritoneal Expression and Estrogen Regulation of Nociceptive Ion Channels in Endometriosis via openalex
Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis via openalex
Emerging drugs for endometriosis via openalex
Endocannabinoid involvement in endometriosis via openalex
Endometrial biomarkers for the non-invasive diagnosis of endometriosis via openalex
Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids via openalex
Endometriosis via openalex
Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery via openalex
Endometriosis-Derived Stromal Cells Secrete Thrombin and Thromboxane A2, Inducing Platelet Activation via openalex
Endometriosis-Related Pelvic Pain: What is the Evidence? via openalex
Endometriosis: the consequence of neurological dysfunction? via openalex
Endometriosis: the consequence of uterine denervation–reinnervation via openalex
Endometriosis: The Role of Neuroangiogenesis via openalex
Endometriosis: What a Pain It Is via openalex
Eutopic endometrium from women with endometriosis does not exhibit neurotrophic properties via openalex
Evaluation of the correlation between endometriosis extent, age of the patients and associated symptomatology. via openalex
Evidence of neurotrophic events due to peritoneal endometriotic lesions via openalex
Functional Connectivity Is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain via openalex
High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis via openalex
Hyperinnervation in Intestinal Deep Infiltrating Endometriosis via openalex
Imbalance between sympathetic and sensory innervation in peritoneal endometriosis via openalex
Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis via openalex
Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries via openalex
Induction of the Neurokinin 1 Receptor by TNFα in Endometriotic Tissue Provides the Potential for Neurogenic Control Over Endometriotic Lesion Growth via openalex
Inflammation and nerve fiber interaction in endometriotic pain via openalex
Influence of Nerve Growth Factor in Endometriosis-Associated Symptoms via openalex
Innervation of ectopic endometrium in a rat model of endometriosis via openalex
Is the Detection of Endometrial Nerve Fibers Useful in the Diagnosis of Endometriosis? via openalex
Levo-Tetrahydropalmatine Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats via openalex
Loss of sympathetic nerve fibers in intestinal endometriosis via openalex
Nerve fiber density in deep nodular endometriotic lesions induced in a baboon experimental model via openalex
Nerve Fibers and Histopathology of Endometriosis-Harboring Peritoneum via openalex
Nerve Fibers are Absent in Disease-Free and Eutopic Endometrium, but Present in Endometriotic (Especially Deep) Lesions via openalex
Nerve fibers in ovarian dermoid cysts and endometriomas via openalex
Nerve fibers in uterosacral ligaments of women with deep infiltrating endometriosis via openalex
Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis via openalex
Nerve fibres in peritoneal endometriosis via openalex
Neuroendocrine cells in eutopic endometrium of women with endometriosis via openalex
Neuroimmunomodulatory Alterations in Non-Lesional Peritoneum Close to Peritoneal Endometriosis via openalex
Neurotrophin Expression Is Not Affected in Uteri of Women with Adenomyosis via openalex
New medical treatments for endometriosis via openalex
Overexpression of nerve growth factor in peritoneal fluid from women with endometriosis may promote neurite outgrowth in endometriotic lesions via openalex
Pain symptoms associated with endometriosis. via openalex
Peripheral changes in endometriosis-associated pain via openalex
Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence via openalex
Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis via openalex
Possible Loss of GABAergic Inhibition in Mice With Induced Adenomyosis and Treatment With Epigallocatechin-3-Gallate Attenuates the Loss With Improved Hyperalgesia via openalex
Potential Role of Semaphorin 3A and Its Receptors in Regulating Aberrant Sympathetic Innervation in Peritoneal and Deep Infiltrating Endometriosis via openalex
Prostaglandin E <sub>2</sub> : the master of endometriosis? via openalex
Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis via openalex
Rich innervation of deep infiltrating endometriosis via openalex
Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats via openalex
The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres via openalex
The Expression and Functionality of Transient Receptor Potential Vanilloid 1 in Ovarian Endometriomas via openalex
The importance of endometrial nerve fibers and macrophage cell count in the diagnosis of endometriosis. via openalex
The Importance of Pelvic Nerve Fibers in Endometriosis via openalex
The Pains of Endometriosis via openalex
The Potential Role of Endometrial Nerve Fibers in the Pathogenesis of Pain During Endometrial Biopsy at Office Hysteroscopy via openalex
Transforming growth factor β1 signaling coincides with epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis in mice via openalex
TRPV1 Expression on Peritoneal Endometriosis Foci is Associated With Chronic Pelvic Pain via openalex
Use of hormonal therapy is associated with reduced nerve fiber density in deep infiltrating, rectovaginal endometriosis via openalex
Uterine innervation after hysterectomy for chronic pelvic pain with, and without, endometriosis via openalex
Uterine innervation in adenomyosis via openalex
Uterosacral nerve fibre proliferation in parous endometriosis via openalex
W2075715972 via openalex
W2005180409 via openalex
W2072553414 via openalex
W1995705528 via openalex
W2078879971 via openalex
W1992638684 via openalex
W1991633723 via openalex
W2084701217 via openalex
W2085922363 via openalex
W2087592242 via openalex
W2088962643 via openalex
W1989231576 via openalex
W2092635728 via openalex

Cited by (40)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-13T22:21:00.404924+00:00

License: CC0 · commercial use OK

[1] Aberrant Expression of Leptin in Human Endometriotic Stromal Cells Is Induced by Elevated Levels of Hypoxia Inducible Factor-1α via openalex

[2] A pilot study to evaluate the clinical relevance of endometriosis-associated nerve fibers in peritoneal endometriotic lesions via openalex

[3] A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibers via openalex

[4] Are endometrial nerve fibres unique to endometriosis? A prospective case–control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain via openalex

[5] Aromatase and other steroidogenic genes in endometriosis: translational aspects via openalex

[6] Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis via openalex

[7] [Cannabinoid receptor 1 controls nerve growth in ectopic cyst in a rat endometriosis model]. via openalex

[8] Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex

[9] Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK/Erk1/2 signal pathway via openalex

[10] Chronic pelvic pain: Cause, diagnosis and therapy from a gynaecologist's and an endoscopist's point of view via openalex

[11] Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis via openalex

[12] Comparative Study of the Neuropeptide-Y Sympathetic Nerves in Endometriotic Involved and Noninvolved Sacrouterine Ligaments in Women with Pelvic Endometriosis via openalex

[13] Correlation between endometriosis-associated dysmenorrhea and the presence of typical or atypical lesions via openalex

[14] Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications via openalex

[15] Density of small diameter sensory nerve fibres in endometrium: a semi-invasive diagnostic test for minimal to mild endometriosis via openalex

[16] Detection of Endometrial Nerve Fibres – a Novel Technique to Diagnose Endometriosis via openalex

[17] Detection of the pan neuronal marker PGP9.5 by immuno-histochemistry and quantitative PCR in eutopic endometrium from women with and without endometriosis via openalex

[18] Diagnosis of endometrial nerve fibers in women with endometriosis via openalex

[19] Differences in uterine innervation at hysterectomy via openalex

[20] Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis via openalex

[21] Ectopic uterine tissue as a chronic pain generator via openalex

[22] Effect of progestogens and combined oral contraceptives on nerve fibers in peritoneal endometriosis via openalex

[23] Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis via openalex

[24] Elevated Peritoneal Expression and Estrogen Regulation of Nociceptive Ion Channels in Endometriosis via openalex

[25] Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis via openalex

[26] Emerging drugs for endometriosis via openalex

[27] Endocannabinoid involvement in endometriosis via openalex

[28] Endometrial biomarkers for the non-invasive diagnosis of endometriosis via openalex

[29] Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids via openalex

[30] Endometriosis via openalex

[31] Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery via openalex

[32] Endometriosis-Derived Stromal Cells Secrete Thrombin and Thromboxane A2, Inducing Platelet Activation via openalex

[33] Endometriosis-Related Pelvic Pain: What is the Evidence? via openalex

[34] Endometriosis: the consequence of neurological dysfunction? via openalex

[35] Endometriosis: the consequence of uterine denervation–reinnervation via openalex

[36] Endometriosis: The Role of Neuroangiogenesis via openalex

[37] Endometriosis: What a Pain It Is via openalex

[38] Eutopic endometrium from women with endometriosis does not exhibit neurotrophic properties via openalex

[39] Evaluation of the correlation between endometriosis extent, age of the patients and associated symptomatology. via openalex

[40] Evidence of neurotrophic events due to peritoneal endometriotic lesions via openalex

[41] Functional Connectivity Is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain via openalex

[42] High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis via openalex

[43] Hyperinnervation in Intestinal Deep Infiltrating Endometriosis via openalex

[44] Imbalance between sympathetic and sensory innervation in peritoneal endometriosis via openalex

[45] Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis via openalex

[46] Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries via openalex

[47] Induction of the Neurokinin 1 Receptor by TNFα in Endometriotic Tissue Provides the Potential for Neurogenic Control Over Endometriotic Lesion Growth via openalex

[48] Inflammation and nerve fiber interaction in endometriotic pain via openalex

[49] Influence of Nerve Growth Factor in Endometriosis-Associated Symptoms via openalex

[50] Innervation of ectopic endometrium in a rat model of endometriosis via openalex

[51] Is the Detection of Endometrial Nerve Fibers Useful in the Diagnosis of Endometriosis? via openalex

[52] Levo-Tetrahydropalmatine Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats via openalex

[53] Loss of sympathetic nerve fibers in intestinal endometriosis via openalex

[54] Nerve fiber density in deep nodular endometriotic lesions induced in a baboon experimental model via openalex

[55] Nerve Fibers and Histopathology of Endometriosis-Harboring Peritoneum via openalex

[56] Nerve Fibers are Absent in Disease-Free and Eutopic Endometrium, but Present in Endometriotic (Especially Deep) Lesions via openalex

[57] Nerve fibers in ovarian dermoid cysts and endometriomas via openalex

[58] Nerve fibers in uterosacral ligaments of women with deep infiltrating endometriosis via openalex

[59] Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis via openalex

[60] Nerve fibres in peritoneal endometriosis via openalex

[61] Neuroendocrine cells in eutopic endometrium of women with endometriosis via openalex

[62] Neuroimmunomodulatory Alterations in Non-Lesional Peritoneum Close to Peritoneal Endometriosis via openalex

[63] Neurotrophin Expression Is Not Affected in Uteri of Women with Adenomyosis via openalex

[64] New medical treatments for endometriosis via openalex

[65] Overexpression of nerve growth factor in peritoneal fluid from women with endometriosis may promote neurite outgrowth in endometriotic lesions via openalex

[66] Pain symptoms associated with endometriosis. via openalex

[67] Peripheral changes in endometriosis-associated pain via openalex

[68] Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence via openalex

[69] Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis via openalex

[70] Possible Loss of GABAergic Inhibition in Mice With Induced Adenomyosis and Treatment With Epigallocatechin-3-Gallate Attenuates the Loss With Improved Hyperalgesia via openalex

[71] Potential Role of Semaphorin 3A and Its Receptors in Regulating Aberrant Sympathetic Innervation in Peritoneal and Deep Infiltrating Endometriosis via openalex

[72] Prostaglandin E <sub>2</sub> : the master of endometriosis? via openalex

[73] Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis via openalex

[74] Rich innervation of deep infiltrating endometriosis via openalex

[75] Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats via openalex

[76] The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres via openalex

[77] The Expression and Functionality of Transient Receptor Potential Vanilloid 1 in Ovarian Endometriomas via openalex

[78] The importance of endometrial nerve fibers and macrophage cell count in the diagnosis of endometriosis. via openalex

[79] The Importance of Pelvic Nerve Fibers in Endometriosis via openalex

[80] The Pains of Endometriosis via openalex

[81] The Potential Role of Endometrial Nerve Fibers in the Pathogenesis of Pain During Endometrial Biopsy at Office Hysteroscopy via openalex

[82] Transforming growth factor β1 signaling coincides with epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis in mice via openalex

[83] TRPV1 Expression on Peritoneal Endometriosis Foci is Associated With Chronic Pelvic Pain via openalex

[84] Use of hormonal therapy is associated with reduced nerve fiber density in deep infiltrating, rectovaginal endometriosis via openalex

[85] Uterine innervation after hysterectomy for chronic pelvic pain with, and without, endometriosis via openalex

[86] Uterine innervation in adenomyosis via openalex

[87] Uterosacral nerve fibre proliferation in parous endometriosis via openalex

[88] W2075715972 via openalex

[89] W2005180409 via openalex

[90] W2072553414 via openalex

[91] W1995705528 via openalex

[92] W2078879971 via openalex

[93] W1992638684 via openalex

[94] W1991633723 via openalex

[95] W2084701217 via openalex

[96] W2085922363 via openalex

[97] W2087592242 via openalex

[98] W2088962643 via openalex

[99] W1989231576 via openalex

[100] W2092635728 via openalex