The Role of Platelets in the Pathogenesis of Endometriosis and New Therapeutic Ideas

血小板在子宫内膜异位症发病机制中的作用及新的治疗思路 The Role of Platelets in the Pathogenesis of Endometriosis and New Therapeutic Ideas The Role of Platelets in the Pathogenesis of Endometriosis and New Therapeutic Ideas DOI: 10.12677/ACM.2022.124367, PDF, 被引量 作者: 许万增, 王慧粉, 陶文康, 史纪芳*：大理大学，云南 大理 关键词: 子宫内膜异位症；血小板；发病机制；药物治疗；Endometriosis； Platelet； Pathogenesis； Drug Therapy 作者: 许万增, 王慧粉, 陶文康, 史纪芳*：大理大学，云南 大理 关键词: 子宫内膜异位症；血小板；发病机制；药物治疗；Endometriosis； Platelet； Pathogenesis； Drug Therapy 摘要: 子宫内膜异位症(Endometriosis, EMT)是一种常见的妇科疾病，它严重影响着女性的身心健康，目前对于子宫内膜异位症的药物治疗仍是以激素类药物为主，但是存在着激素类药物相关的副作用，且并不能从根本上解决问题。随着对于子宫内膜异位症发病机制的研究逐渐深入，血小板在EMT发病过程中的作用逐渐被揭示，它在疾病发展过程中的局部炎症反应、免疫调节的失调、雌激素产生的增加、组织细胞的缺氧等诸多方面起着重要作用，这也为我们探索激素类药物之外的治疗方案提供了新的思路。本文就血小板在EMT的发生发展过程中起的作用进行综述，同时探讨抗血小板治疗在EMT治疗中的可行性。 Abstract: Endometriosis (EMT) is a common gynecological disease, which seriously affects the physical and mental health of women, at present, the drug treatment of endometriosis is still mainly hormone drugs, but there are hormone-related side effects, and can’t fundamentally solve the problem. With the in-depth study of the pathogenesis of endometriosis, the role of platelets in the pathogenesis of EMT has been gradually revealed, and it plays an important role in many aspects, such as local inflammatory reaction, imbalance of immune regulation, increase of estrogen production, hypoxia of tissues and cells, etc., which also provides a new idea for us to explore treatments other than hormone drugs. This article reviews the role of platelets in the occurrence and development of EMT, and discusses the feasibility of antiplatelet therapy in EMT treatment. 文章引用：许万增, 王慧粉, 陶文康, 史纪芳. 血小板在子宫内膜异位症发病机制中的作用及新的治疗思路[J]. 临床医学进展, 2022, 12(4): 2546-2551. https://doi.org/10.12677/ACM.2022.124367 | [1] | Giudice, L.C. and Kao, L.C. (2004) Endometriosis. The Lancet, 364, 1789-1799. [Google Scholar] [CrossRef] | | [2] | Singh, S.S. and Suen, M.W. (2017) Surgery for Endometriosis: Beyond Medical Therapies. Fertility and Sterility, 107, 549-554. 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