Comparative Study of the Neuropeptide-Y Sympathetic Nerves in Endometriotic Involved and Noninvolved Sacrouterine Ligaments in Women with Pelvic Endometriosis

Marc Possover, Possover M, Plamen Tersiev, Tersiev P, Angelov DN, Doychin N. Angelov
Journal of Minimally Invasive Gynecology · 2009 · vol. 16(3) , pp. 340–343 · doi:10.1016/j.jmig.2009.02.012 · PMID:19423065 · W2004594724
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This study investigated the density of neuropeptide-Y sympathetic nerves in sacrouterine ligaments from women with and without endometriosis.

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Abstract

Study objectiveTo show the relationship between the neuropeptide-Y pelvic sympathetic nerves and neoangiogenesis in the development of endometriosisDesignProspective study.SettingAcademic community teaching hospital.PatientsFifteen consecutive women with unilateral endometriotic infiltration of the sacrouterine ligaments.InterventionsA laparoscopic excision/biopsy of involved and noninvolved parts of the sacrouterine ligaments were taken. The sections were incubated with the neuronal marker rabbit polyclonal anti-protein gene product 9.5 and rabbit polyclonal anti-neuropeptide-Y. We made a comparative study on the distribution of nerve fibers and their relationship to the vessels on intact and endometriotic involved tissue.Measurements and main resultsThe results show that a large amount of nerves are present around the blood vessels in the endometriosis samples, and a large number of these nerves are neuropeptide-Y sympathetic nerves. Adrenergic fibers are also present in the intact control subjects, however, in significantly smaller amounts.ConclusionThis finding shows a strong relationship between the neuropeptide-Y sympathetic pelvic nerves and the neoangiogenesis required for the development of endometriosis.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Ligaments Neovascularization, Pathologic Neuropeptide Y Sympathetic Nervous System Adult Biopsy Endometriosis Endometriosis Female Humans Ligaments Ligaments Ligaments Neovascularization, Pathologic Neuropeptide Y Pelvic Pain Prospective Studies Sympathetic Nervous System Young Adult

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