Expressão de mediadores neurotróficos e pró-inflamatórios na endometriose de reto e sigmoide

Fábio Sakae Kuteken, Carmen Lucia Penteado Lancellotti, Carmen Lúcia Penteado Lancellotti, Helizabet Salomão Abdalla Ayroza Ribeiro, José Mendes Aldrighi, Paulo Augusto Ayroza Galvão Ribeiro, Paulo Ayroza Ribeiro
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2012 · vol. 34(12) , pp. 568–574 · doi:10.1590/s0100-72032012001200007 · PMID:23329287 · W1971687730
article OA: diamond CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study found increased expression of TNF-α and NGF in rectal and sigmoid endometriosis tissue compared to healthy controls, with no significant difference in NPY or VIP expression.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study evaluated expression of neurotrophic mediators (NGF, NPY, VIP) and the pro-inflammatory mediator TNF-α in rectum and sigmoid tissue fragments affected by deep infiltrating endometriosis. Twenty-four premenopausal patients undergoing segmental resection with end-to-end anastomosis were included, with one histologically confirmed endometriosis fragment per patient analyzed on tissue microarrays, and a distal resection margin “anastomosis ring” fragment from the same patients used as controls; immunohistochemistry was quantified semiquantitatively using relative optical density, with statistical significance reported for TNF-α and NGF but not for NPY or VIP. The authors found higher relative optical density for TNF-α and NGF in endometriosis-affected samples versus controls (p<0.05), with no statistically significant difference for NPY and VIP, and the main caveat is that only selected mediators and a limited sampling strategy were assessed. This paper is centrally about endometriosis — it focuses specifically on neurotrophic and pro-inflammatory mediator expression in rectosigmoid deep infiltrating endometriosis.

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Abstract

PURPOSE: To evaluate the expression of neurotrophic (NGF, NPY and VIP) and pro-inflammatory (TNF-α) mediators in the rectum and sigmoid fragments compromised by endometriosis. METHODS: Twenty-four patients were selected to undergo surgical treatment of endometriosis of the rectum and sigmoid colon with a segmental resection technique, followed by end-to-end anastomosis with a circular stapler from January 2005 to December 2007. The study included premenopausal women who underwent surgical treatment for deep endometriosis infiltrating the rectum with involvement of the rectum and sigmoid, reaching the level of the muscle layer, submucosa or mucosa. Twenty-four rectum and sigmoid fragments with histologically confirmed endometriosis, one from each of the 24 selected patients, were used for the study group. For the control group, we used a fragment of the distal resection margin called anastomosis ring from each of the 24 patients enrolled in the study. Samples were grouped into Tissue Micro Array (TMA) blocks and subjected to immunohistochemistry to evaluate the expression of tumor necrosis factor alpha (TNF-α), nerve growth factor (NGF), neuropeptide Y (NPY) and P vasoactive intestinal peptide (VIP), followed by semiquantitative analysis of immunostaining by reading the relative optical density (OD). RESULTS: There was higher optical density relative to TNF-α immunostaining and NGF in the study group (samples with intestinal endometriosis), DO=0.01, for the two proteins, respectively (p<0.05), compared to controls without endometriosis. There was no statistically significant difference in the optical density of immunostaining of NPY and VIP. CONCLUSION: We identified increased immunostaining of TNF-α antibodies and fragments of NGF in the rectum and sigmoid compromised by endometriosis compared to disease-free controls. We did not identify any statistical difference in immunostaining of NPY and VIP proteins.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Nerve Growth Factor Neuropeptide Y Rectal Diseases Sigmoid Diseases Tumor Necrosis Factor-alpha Vasoactive Intestinal Peptide Adult Cross-Sectional Studies Endometriosis Female Humans Middle Aged Nerve Growth Factor Neuropeptide Y Rectal Diseases Sigmoid Diseases Tumor Necrosis Factor-alpha Vasoactive Intestinal Peptide

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