Oxidative stress and peritoneal endometriosis

Anne Van Langendonckt, Van Langendonckt A, Françoise Casanas‐Roux, Françoise Casanas-Roux, Casanas-Roux F, Jacques Donnez, Donnez J
Fertility and sterility · 2002 · vol. 77(5) , pp. 861–870 · doi:10.1016/s0015-0282(02)02959-x · PMID:12009336 · W2070404547
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This paper investigates the role of oxidative stress in peritoneal endometriosis and its effects on cellular function and disease progression.

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Abstract

OBJECTIVE: To review the literature associating pelvic endometriosis with oxidative stress and to discuss the potential causes and consequences of a pro-oxidant environment in the peritoneal cavity. DESIGN: Literature survey. RESULT(S): Several studies suggest that oxidative stress is a component of the inflammatory reaction associated with endometriosis. Evidence includes the prevention of endometriosis induction in rabbits by the addition of antioxidants, an increase in reactive oxygen species release by macrophages, increased peritoneal levels of oxidized low-density lipoproteins and their by-products, altered expression of endometrial pro-oxidant and antioxidant enzymes, and consumption of peritoneal fluid vitamin E. Retrograde menstruation is likely to carry highly pro-oxidant factors, such as heme and iron, into the peritoneal cavity, as well as apoptotic endometrial cells, which are well-known inducers of oxidative stress. Reactive oxygen species may be involved in endometriosis-associated infertility and may play a role in the regulation of the expression of genes encoding immunoregulators, cytokines and cell adhesion molecules implicated in the pathogenesis of endometriosis. CONCLUSION(S): Better understanding of the mechanisms of reactive oxygen species production and detoxification and further investigation of their effect on the peritoneal environment are essential to obtain new insight into this disease and eventually develop new diagnostic and therapeutic strategies.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Oxidative Stress Oxidative Stress Peritoneal Diseases Animals Animals Endometriosis Endometriosis Female Female Humans Humans Peritoneal Cavity Peritoneal Cavity Peritoneal Cavity Peritoneal Diseases Peritoneal Diseases Reactive Oxygen Species Reactive Oxygen Species Reactive Oxygen Species

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

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