Angiogenesis and antiangiogenic therapy in endometriosis

Becker CM, Christian M. Becker, D'Amato RJ, Robert J D'Amato, Robert J. D’Amato
Microvascular research · 2007 · vol. 74(2-3) , pp. 121–130 · doi:10.1016/j.mvr.2007.04.008 · PMID:17574280 · W2023282968
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This paper reviews the role of angiogenesis and antiangiogenic therapies in the context of endometriosis.

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Abstract

Endometriosis, the presence of endometrium-like tissue outside of the uterine cavity, is a common disease among women of reproductive age. Typical symptoms include abdominal pain and painful menstruation. In addition, endometriosis is associated with reduced fertility. Current treatment modalities, the surgical removal of endometriotic lesions and the hormonal suppression of estrogen are associated with significant morbidity, side-effects and recurrence rates. Despite uncertainties about the pathophysiology of the disease it has recently become apparent that angiogenesis plays a pivotal role in endometriosis. This review focuses on a multitude of factors involved in the angiogenic phenotype of endometriosis demonstrating that many biological systems such as the immune system and steroid hormones are closely connected to angiogenic pathways in this disease. In addition, experimental and clinical data are discussed that concentrate on the inhibition of angiogenesis as a novel therapeutic approach for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Angiogenesis Inhibitors Cytokines Endometriosis Hormones Neovascularization, Pathologic Vascular Endothelial Growth Factor A Angiogenesis Inhibitors Angiogenesis Inhibitors Animals Animals Cytokines Cytokines Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Hormones

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

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License: CC0 · commercial use OK