Role of AMPK/mTOR, mitochondria, and ROS in the pathogenesis of endometriosis

Lama Assaf; Assaad A Eid; Joseph Nassif

doi:10.1016/j.lfs.2022.120805

Role of AMPK/mTOR, mitochondria, and ROS in the pathogenesis of endometriosis

Lama Assaf, Assaad A Eid, Joseph Nassif

Life sciences · 2022 · vol. 306 , pp. 120805 · doi:10.1016/j.lfs.2022.120805 · PMID:35850246 · W4285606011

review OA: closed CC0 ⤵ 49 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the roles of AMPK/mTOR signaling, mitochondria, and reactive oxygen species (ROS) in endometriosis development.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis AMP-Activated Protein Kinases AMP-Activated Protein Kinases AMP-Activated Protein Kinases AMP-Activated Protein Kinases AMP-Activated Protein Kinases AMP-Activated Protein Kinases AMP-Activated Protein Kinases Female Female Female Female Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Activated AKT Pathway Promotes Establishment of Endometriosis via openalex
Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC–ERK1/2–mTOR signaling pathway via openalex
Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture via openalex
Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis via openalex
Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis via openalex
Antifibrotic properties of epigallocatechin-3-gallate in endometriosis via openalex
An unusual cause of abdominal pain in a male patient: Endometriosis via openalex
A potential link of oxidative stress and cell cycle regulation for development of endometriosis via openalex
Autophagy in endometriosis. via openalex
Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies via openalex
Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis. via openalex
Costunolide Induces Apoptosis in Human Endometriotic Cells through Inhibition of the Prosurvival Akt and Nuclear Factor Kappa B Signaling Pathway via openalex
Deep Quantitative Proteomics Reveals Extensive Metabolic Reprogramming and Cancer-Like Changes of Ectopic Endometriotic Stromal Cells via openalex
Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts via openalex
Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis via openalex
Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS? via openalex
Dynamics of nitric oxide, altered follicular microenvironment, and oocyte quality in women with endometriosis via openalex
Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis via openalex
Effect of vitamin <scp>C</scp> on the growth of experimentally induced endometriotic cysts via openalex
Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial via openalex
Effects of atorvastatin and resveratrol against the experimental endometriosis; evidence for glucose and monocarboxylate transporters, neoangiogenesis via openalex
Endometriosis and Infertility via openalex
Endometriosis: Epidemiology, Diagnosis and Clinical Management via openalex
Endometriosis in Menopause—Renewed Attention on a Controversial Disease via openalex
Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly via openalex
Endometriosis: pathogenesis and treatment via openalex
Epithelial-to-mesenchymal transition in the development of endometriosis via openalex
Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis via openalex
Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex
HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression via openalex
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation via openalex
Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis via openalex
In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis via openalex
Immunohistochemical assessment of superoxide dismutase expression in the endometrium in endometriosis and adenomyosis via openalex
Increased expression of CYP1A1 and CYP1B1 in ovarian/peritoneal endometriotic lesions via openalex
Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility via openalex
Inflammation and endometriosis via openalex
Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model via openalex
Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics via openalex
Leflunomide—an Immunomodulator—Induces Regression of Endometrial Explants in a Rat Model of Endometriosis via openalex
Low-Density Lipoproteins Oxidation and Endometriosis via openalex
Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF via openalex
Measurable serum markers of oxidative stress response in women with endometriosis via openalex
Metformin InhibitsStARExpression in Human Endometriotic Stromal Cells via AMPK-Mediated Disruption of CREB-CRTC2 Complex Formation via openalex
Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells via openalex
Mitochondria and oxidative stress in ovarian endometriosis via openalex
Mitochondria DNA Polymorphisms Are Associated with Susceptibility to Endometriosis via openalex
Mitochondrial displacement loop alterations are associated with endometriosis via openalex
More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis via openalex
Nitric oxide synthesis is increased in the endometrial tissue of women with endometriosis via openalex
Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex
Oxidative stress and endometriosis via openalex
Oxidative Stress Statues in Serum and Follicular Fluid of Women with Endometriosis. via openalex
Pathogenesis of endometriosis via openalex
Pathogenetic Mechanisms of Deep Infiltrating Endometriosis via openalex
Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex
Protein oxidative stress markers in peritoneal fluids of women with deep infiltrating endometriosis are increased via openalex
Reactive Oxygen Species Controls Endometriosis Progression via openalex
Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis via openalex
Regulation of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Endometriotic Stromal Cells via openalex
Repurposing dichloroacetate for the treatment of women with endometriosis via openalex
Resveratrol and Endometrium: A Closer Look at an Active Ingredient of Red Wine Using In Vivo and In Vitro Models via openalex
Rethinking mechanisms, diagnosis and management of endometriosis via openalex
Role of 8-iso-prostaglandin F2α and 25-hydroxycholesterol in the pathophysiology of endometriosis via openalex
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex
The inhibition of reactive oxygen species (ROS) by antioxidants inhibits the release of an autophagy marker in ectopic endometrial cells via openalex
The mTOR/AKT Inhibitor Temsirolimus Prevents Deep Infiltrating Endometriosis in Mice via openalex
THE PATHOGENESIS OF ENDOMETRIOSIS via openalex
The role of NADPH-derived reactive oxygen species production in the pathogenesis of endometriosis: a novel mechanistic approach. via openalex
The Role of the Lymphatic System in Endometriosis: A Comprehensive Review of the Literature1 via openalex
Toll‐like receptor system and endometriosis via openalex
Transforming Growth Factor-β Induced Warburg-Like Metabolic Reprogramming May Underpin the Development of Peritoneal Endometriosis via openalex
Was Sampson wrong? via openalex
W2049368067 via openalex
W2128410150 via openalex
W2129778797 via openalex
W2134907909 via openalex
W2048530835 via openalex
W2135387190 via openalex
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W2151260260 via openalex
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W2164140081 via openalex
W2165321074 via openalex
W2165667160 via openalex
W2030344369 via openalex
W2025351482 via openalex
W2023062971 via openalex
W2184995059 via openalex
W2195415518 via openalex
W2269880005 via openalex

Cited by (49)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-25T00:34:41.078561+00:00

License: CC0 · commercial use OK

[1] Activated AKT Pathway Promotes Establishment of Endometriosis via openalex

[2] Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC–ERK1/2–mTOR signaling pathway via openalex

[3] Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture via openalex

[4] Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis via openalex

[5] Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis via openalex

[6] Antifibrotic properties of epigallocatechin-3-gallate in endometriosis via openalex

[7] An unusual cause of abdominal pain in a male patient: Endometriosis via openalex

[8] A potential link of oxidative stress and cell cycle regulation for development of endometriosis via openalex

[9] Autophagy in endometriosis. via openalex

[10] Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies via openalex

[11] Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis. via openalex

[12] Costunolide Induces Apoptosis in Human Endometriotic Cells through Inhibition of the Prosurvival Akt and Nuclear Factor Kappa B Signaling Pathway via openalex

[13] Deep Quantitative Proteomics Reveals Extensive Metabolic Reprogramming and Cancer-Like Changes of Ectopic Endometriotic Stromal Cells via openalex

[14] Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts via openalex

[15] Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis via openalex

[16] Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS? via openalex

[17] Dynamics of nitric oxide, altered follicular microenvironment, and oocyte quality in women with endometriosis via openalex

[18] Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis via openalex

[19] Effect of vitamin <scp>C</scp> on the growth of experimentally induced endometriotic cysts via openalex

[20] Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial via openalex

[21] Effects of atorvastatin and resveratrol against the experimental endometriosis; evidence for glucose and monocarboxylate transporters, neoangiogenesis via openalex

[22] Endometriosis and Infertility via openalex

[23] Endometriosis: Epidemiology, Diagnosis and Clinical Management via openalex

[24] Endometriosis in Menopause—Renewed Attention on a Controversial Disease via openalex

[25] Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly via openalex

[26] Endometriosis: pathogenesis and treatment via openalex

[27] Epithelial-to-mesenchymal transition in the development of endometriosis via openalex

[28] Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis via openalex

[29] Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex

[30] HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression via openalex

[31] Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation via openalex

[32] Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis via openalex

[33] <i>In vitro</i> and <i>in vivo</i> effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis via openalex

[34] Immunohistochemical assessment of superoxide dismutase expression in the endometrium in endometriosis and adenomyosis via openalex

[35] Increased expression of <i>CYP1A1</i> and <i>CYP1B1</i> in ovarian/peritoneal endometriotic lesions via openalex

[36] Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility via openalex

[37] Inflammation and endometriosis via openalex

[38] Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model via openalex

[39] Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics via openalex

[40] Leflunomide—an Immunomodulator—Induces Regression of Endometrial Explants in a Rat Model of Endometriosis via openalex

[41] Low-Density Lipoproteins Oxidation and Endometriosis via openalex

[42] Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF via openalex

[43] Measurable serum markers of oxidative stress response in women with endometriosis via openalex

[44] Metformin Inhibits<i>StAR</i>Expression in Human Endometriotic Stromal Cells via AMPK-Mediated Disruption of CREB-CRTC2 Complex Formation via openalex

[45] Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells via openalex

[46] Mitochondria and oxidative stress in ovarian endometriosis via openalex

[47] Mitochondria DNA Polymorphisms Are Associated with Susceptibility to Endometriosis via openalex

[48] Mitochondrial displacement loop alterations are associated with endometriosis via openalex

[49] More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis via openalex

[50] Nitric oxide synthesis is increased in the endometrial tissue of women with endometriosis via openalex

[51] Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex

[52] Oxidative stress and endometriosis via openalex

[53] Oxidative Stress Statues in Serum and Follicular Fluid of Women with Endometriosis. via openalex

[54] Pathogenesis of endometriosis via openalex

[55] Pathogenetic Mechanisms of Deep Infiltrating Endometriosis via openalex

[56] Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex

[57] Protein oxidative stress markers in peritoneal fluids of women with deep infiltrating endometriosis are increased via openalex

[58] Reactive Oxygen Species Controls Endometriosis Progression via openalex

[59] Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis via openalex

[60] Regulation of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Endometriotic Stromal Cells via openalex

[61] Repurposing dichloroacetate for the treatment of women with endometriosis via openalex

[62] Resveratrol and Endometrium: A Closer Look at an Active Ingredient of Red Wine Using In Vivo and In Vitro Models via openalex

[63] Rethinking mechanisms, diagnosis and management of endometriosis via openalex

[64] Role of 8-iso-prostaglandin F2α and 25-hydroxycholesterol in the pathophysiology of endometriosis via openalex

[65] The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex

[66] The inhibition of reactive oxygen species (ROS) by antioxidants inhibits the release of an autophagy marker in ectopic endometrial cells via openalex

[67] The mTOR/AKT Inhibitor Temsirolimus Prevents Deep Infiltrating Endometriosis in Mice via openalex

[68] THE PATHOGENESIS OF ENDOMETRIOSIS via openalex

[69] The role of NADPH-derived reactive oxygen species production in the pathogenesis of endometriosis: a novel mechanistic approach. via openalex

[70] The Role of the Lymphatic System in Endometriosis: A Comprehensive Review of the Literature1 via openalex

[71] Toll‐like receptor system and endometriosis via openalex

[72] Transforming Growth Factor-β Induced Warburg-Like Metabolic Reprogramming May Underpin the Development of Peritoneal Endometriosis via openalex

[73] Was Sampson wrong? via openalex

[74] W2049368067 via openalex

[75] W2128410150 via openalex

[76] W2129778797 via openalex

[77] W2134907909 via openalex

[78] W2048530835 via openalex

[79] W2135387190 via openalex

[80] W2135414744 via openalex

[81] W2039830942 via openalex

[82] W2038009564 via openalex

[83] W2135935849 via openalex

[84] W2035353547 via openalex

[85] W2137108265 via openalex

[86] W2142583550 via openalex

[87] W2035007000 via openalex

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