Role of oxidative protein destruction products in the external genital endometriosis pathogenesis and progression

MV Osikov, IV Kurnosenko, VA Kryukov, VA Bivalkevich, VA Sumerkina
In: Bulletin of Russian State Medical University · 2026 · doi:10.24075/brsmu.2026.031 · W7166559326
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This study found that higher levels of oxidative protein modification products and lower reserve-adaptative potential in ectopic endometrium correlated with more severe stages of external genital endometriosis.

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This original research evaluated oxidative protein modification (OPM) products in ectopic endometrium homogenates from 28 women with histologically verified external genital endometriosis, stratifying participants into AAGL stages II–III (n=10) and stage IV (n=18). Using spectrophotometry, the authors found that total OPM products, basic aldehyde-dinitrophenylhydrazones, and total ketone-dinitrophenylhydrazones were significantly higher in stage IV than in stages II–III, along with significantly lower reserve-adaptive potential in stage IV. Correlation analyses showed positive associations between disease severity and the intergroup-differing OPM measures, and a negative association between severity and reserve-adaptive potential. The study’s main caveat is the small sample size and cross-sectional design without reporting longitudinal outcomes. This paper is centrally about endometriosis—specifically the role of oxidative protein destruction products in the pathogenesis and progression of external genital endometriosis.

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Abstract

External genital endometriosis is characterized by high prevalence. Despite unquestionable role of oxidative stress in the development of endometriosis, its features associated with the disease progression are poorly understood. The study aimed to assess the role of oxidative protein modification (OPM) products in the disease progression. A total of 28 women with the established and histologically verified diagnosis of endometriosis took part in the study. The subjects were stratified into group 1 (stage II–III, n = 10) and group 2 (stage IV, n = 18) based on the disease stage in accordance with the American Association of Gynecologic Laparoscopists (AAGL) classification. The content of OPM products in the ectopic endometrium homogenate was determined by spectrophotometry. The following indicators were significantly higher in patients of group 2, than in patients of group 1: the total OPM product content (p = 0.040), basic aldehyde-dinitrophenylhydrazones (p = 0.039), and the total amount of ketone-dinitrophenylhydrazones (p = 0.024). Furthermore, women of group 2 showed significantly lower reserve-adaptative potential values, than patients of group 1 (p = 0.045). We found a positive correlation between the disease severity and the content of OPM products showing intergroup differences (R between 0.397 and 0.443, p < 0.05), along with the negative correlation with the reserve-adaptative potential (R = –0.388, p = 0.042) based on the correlation analysis results. According to the data obtained, the oxidative stress activity in endometriosis foci was correlated with the disease severity. Furthermore, accumulation of OPM products and depletion of the tissue adaptive capacity are typical.
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY). ORIGINAL RESEARCH Role of oxidative protein destruction products in the external genital endometriosis pathogenesis and progression 1 South Ural State Medical University, Chelyabinsk, Russia 2 Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russia Correspondence should be addressed: Vladimir А. Kryukov Ovchinnikova 22, kv. 120, Chelyabinsk, 454011, Russia; ur.kb@29-kihcvov Author contribution: Osikov MV, Kurnosenko IV — developing the research idea, concept and design, editing and approving the final version of the manuscript; Kryukov VA — developing the research design, data acquisition and statistical processing, data interpretation, manuscript writing and editing. Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University (protocol No. 2 dated 05 May 2025). All subjects submitted the informed consent to take part in the study. External genital endometriosis is characterized by high prevalence. Despite unquestionable role of oxidative stress in the development of endometriosis, its features associated with the disease progression are poorly understood. The study aimed to assess the role of oxidative protein modification (OPM) products in the disease progression. A total of 28 women with the established and histologically verified diagnosis of endometriosis took part in the study. The subjects were stratified into group 1 (stage II–III, n = 10) and group 2 (stage IV, n = 18) based on the disease stage in accordance with the American Association of Gynecologic Laparoscopists (AAGL) classification. The content of OPM products in the ectopic endometrium homogenate was determined by spectrophotometry. The following indicators were significantly higher in patients of group 2, than in patients of group 1: the total OPM product content (p = 0.040), basic aldehyde-dinitrophenylhydrazones (p = 0.039), and the total amount of ketone-dinitrophenylhydrazones (p = 0.024). Furthermore, women of group 2 showed significantly lower reserve-adaptative potential values, than patients of group 1 (p = 0.045). We found a positive correlation between the disease severity and the content of OPM products showing intergroup differences (R between 0.397 and 0.443, p < 0.05), along with the negative correlation with the reserve-adaptative potential (R = –0.388, p = 0.042) based on the correlation analysis results. According to the data obtained, the oxidative stress activity in endometriosis foci was correlated with the disease severity. Furthermore, accumulation of OPM products and depletion of the tissue adaptive capacity are typical. Keywords: oxidative stress, endometriosis, oxidative protein modification, advanced external genital endometriosis, endometriosis markers

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