Oxidative Imbalance in Endometriosis-Related Infertility-The Therapeutic Role of Antioxidants

Dymanowska-Dyjak I; Izabela Dymanowska-Dyjak; Karolina Frankowska; Monika Abramiuk; Grzegorz Polak

doi:10.3390/ijms25126298

Oxidative Imbalance in Endometriosis-Related Infertility-The Therapeutic Role of Antioxidants

Dymanowska-Dyjak I, Izabela Dymanowska-Dyjak, Karolina Frankowska, Monika Abramiuk, Grzegorz Polak

International journal of molecular sciences · 2024 · vol. 25(12) , pp. 6298 · doi:10.3390/ijms25126298 · PMID:38928002 · W4399438832

Review OA: gold CC0 ⤵ 10 in-corpus citations

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This review analyzes how antioxidants like vitamins, NAC, curcumin, melatonin, and resveratrol alleviate oxidative stress and inflammation, potentially improving fertility in women with endometriosis.

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Abstract

Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility is caused by a wide range of abnormalities affecting the female reproductive tract, from oocyte quality impairment to disturbances in the eutopic endometrium or mechanical abnormalities resulting from disease progression. Since supportive antioxidant therapies, in addition to surgical treatment or assisted reproductive techniques (ARTs), have overall been proven to be effective tools in endometriosis management, the objective of our review was to analyze the role of antioxidant substances, including vitamins, micronutrients, N-acetylcysteine (NAC), curcumin, melatonin, and resveratrol, in endometriosis-related infertility. Most of these substances have been proven to alleviate the systemic oxidant predominance, which has been expressed through decreased oxidative stress (OS) markers and enhanced antioxidative defense. In addition, we demonstrated that the predominant effect of the aforementioned substances is the inhibition of the development of endometriotic lesions as well as the suppression of pro-inflammatory molecules. Although we can undoubtedly conclude that antioxidants are beneficial in fertility support, further studies explaining the detailed pathways of their action are needed.

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Condition tags

endometriosisinfertility

MeSH descriptors

Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (18)

SciLite annotations

chemicals 4

n-acetylcystathionine curcumin melatonin resveratrol

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[1] Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain via openalex

[2] Antioxidants for female subfertility via openalex

[3] Antioxidant supplementation reduces endometriosis-related pelvic pain in humans via openalex

[4] Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis via openalex

[5] A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine via openalex

[6] A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-α 2 expression in endometriosis women via openalex

[7] Blood biomarkers for the non-invasive diagnosis of endometriosis via openalex

[8] Coenzyme Q10 improves the in vitro maturation of oocytes exposed to the intrafollicular environment of patients on fertility treatment via openalex

[9] Comparing the effect of adjunctive N-acetylcysteine plus low dose contraceptive with low dose contraceptive alone on recurrence of ovarian endometrioma and chronic pelvic pain after conservative laparoscopic surgery: a randomised clinical trial study via openalex

[10] Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity via openalex

[11] Curcumin as anti-endometriotic agent: implication of MMP-3 and intrinsic apoptotic pathway via openalex

[12] Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF-κB signaling pathway via openalex

[13] Curcumin attenuates TNF-α-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells via openalex

[14] Curcumin delays endometriosis development by inhibiting MMP-2 activity via openalex

[15] Curcumin improves growth factors expression of bovine cumulus-oocyte complexes cultured in peritoneal fluid of women with endometriosis via openalex

[16] Curcumin-loaded nanofibers for targeting endometriosis in the peritoneum of a mouse model via openalex

[17] Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis via openalex

[18] Curcumin treats endometriosis in mice by the HIF signaling pathway via openalex

[19] Cyclooxygenase-2 in Endometriosis via openalex

[20] Decreased zinc and increased lead blood levels are associated with endometriosis in Asian Women via openalex

[21] Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis via openalex

[22] Dysregulation of X-ray repair cross-complementing 4 expression in the eutopic endometrium of women with endometriosis via openalex

[23] Effect of Antioxidant Supplementation on Endometriosis-Related Pain: A Systematic Review via openalex

[24] Effect of vitamin C on the growth of experimentally induced endometriotic cysts via openalex

[25] Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis via openalex

[26] Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial via openalex

[27] Effects of vitamin C on the outcome of in vitro fertilization-embryo transfer in endometriosis: A randomized controlled study via openalex

[28] Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes via openalex

[29] Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis via openalex

[30] Endometriosis-associated infertility: From pathophysiology to tailored treatment via openalex

[31] Epidemiology of infertility in women with endometriosis via openalex

[32] Evaluation of serum cancer antigen 125, resistin, leptin, homocysteine, and total antioxidant capacity in rat model of endometriosis treated with Curcumin via openalex

[33] Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility via openalex

[34] Higher Oxidative Stress in Endometriotic Lesions Upregulates Senescence-Associated p16ink4a and β-Galactosidase in Stromal Cells via openalex

[35] How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis? via openalex

[36] Inhibitory effect of curcumin in human endometriosis endometrial cells via downregulation of vascular endothelial growth factor via openalex

[37] Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis via openalex

[38] Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis-associated infertility patients via openalex

[39] In vivo effects of curcumin and deferoxamine in experimental endometriosis via openalex

[40] Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity via openalex

[41] Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling via openalex

[42] Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models via openalex

[43] Lipid peroxidation and vitamin E in serum and follicular fluid of infertile women with peritoneal endometriosis submitted to controlled ovarian hyperstimulation: a pilot study via openalex

[44] Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF via openalex

[45] Melatonin activity and receptor expression in endometrial tissue and endometriosis via openalex

[46] Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases via openalex

[47] Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs via openalex

[48] Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model via openalex

[49] Mitochondrial NADH:ubiquinone oxidoreductase alterations are associated with endometriosis via openalex

[50] More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis via openalex

[51] Natural therapies assessment for the treatment of endometriosis via openalex

[52] Nutrition in the prevention and treatment of endometriosis: A review via openalex

[53] Oxidative phosphorylation inhibitors inhibit proliferation of endometriosis cells via openalex

[54] Oxidative stress and female infertility: the role of follicular fluid soluble receptor of advanced glycation end-products (sRAGE) in women with endometriosis via openalex

[55] Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility via openalex

[56] Oxidative stress biomarkers in patients with endometriosis: systematic review via openalex

[57] Oxidative stress-related effects on various aspects of endometriosis via openalex

[58] Pathophysiology, diagnosis, and management of endometriosis via openalex

[59] Reactive oxygen species controls endometriosis progression via openalex

[60] Regression of endometrial explants in a rat model of endometriosis treated with melatonin via openalex

[61] Regression of endometrial implants by resveratrol in an experimentally induced endometriosis model in rats via openalex

[62] Resveratrol impairs cellular mechanisms associated with the pathogenesis of endometriosis via openalex

[63] Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro via openalex

[64] Resveratrol is a potent inhibitor of vascularization and cell proliferation in experimental endometriosis via openalex

[65] Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway via openalex

[66] Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells via openalex

[67] Role of inflammation and aromatase expression in the eutopic endometrium and its relationship with the development of endometriosis via openalex

[68] Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis via openalex

[69] Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis via openalex

[70] The effectiveness of antioxidant therapy (vitamin C) in an experimentally induced mouse model of ovarian endometriosis via openalex

[71] The effectiveness of Rutin for prevention of surgical induced endometriosis development in a rat model via openalex

[72] The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial via openalex

[73] The effects of different doses of melatonin treatment on endometrial implants in an oophorectomized rat endometriosis model via openalex

[74] The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study via openalex

[75] The effects of melatonin on endometriotic lesions induced by implanting human endometriotic cells in the first SCID-mouse endometriosis-model developed in Turkey via openalex

[76] The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis via openalex

[77] The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial via openalex

[78] The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target via openalex

[79] The Role of Oxidative Stress in Infertility via openalex

[80] The role of the oxidative-stress in the endometriosis-related infertility via openalex

[81] The therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley rats via openalex

[82] TNFα-Induced Altered miRNA Expression Links to NF-κB Signaling Pathway in Endometriosis via openalex

[83] Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model via openalex

[84] Vitamin C is effective for the prevention and regression of endometriotic implants in an experimentally induced rat model of endometriosis via openalex

[85] Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet via openalex

[86] Zinc deficiency is associated with the development of ovarian endometrial cysts via openalex

[87] W4211059826 via openalex

[88] W4214754424 via openalex

[89] W4220784325 via openalex

[90] W4226467596 via openalex

[91] W4234160457 via openalex

[92] W4280576725 via openalex

[93] W4282914148 via openalex

[94] W2133928013 via openalex

[95] W2101204234 via openalex

[96] W2084251750 via openalex

[97] W4318586258 via openalex

[98] W2079190330 via openalex

[99] W4322770763 via openalex

[100] W4328135802 via openalex