The Role of Oxidative Stress in Infertility

Ioana Alexandra Zaha, Ioana Zaha, Mariana Mureşan, Mariana Muresan, Camelia Tulcan, Anca Huniadi, Petronela Naghi, M. Șandor, Roberta Tripon, Cristina Gașpar, Cristina Gaspar, Major Klaudia-Melinda, Liliana Sachelarie, Liana Ștefan, Liana Stefan
Journal of personalized medicine · 2023 · vol. 13(8) , pp. 1264 · doi:10.3390/jpm13081264 · PMID:37623514 · PMC10455473 · W4385840486
article OA: gold CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that higher total antioxidant capacity in follicular fluid correlated with a better pregnancy rate, and lower malondialdehyde levels were observed in the control group during IVF.

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Abstract

(1) Background: Oxidative stress markers in the follicular fluid and serum of the patient with IVF results (number of fertilized oocytes, number of embryos, cumulative pregnancy rate) are important in establishing the causes of infertility. (2) Methods: 42 patients were enrolled in the study over the duration of 24 months and were divided into two groups: the study group divided into the female etiology for infertility as a tubal factor, diminished ovarian reserve, endometriosis, and unexplained infertility, and the control group consisting of the male factor, excluding the sperm donors and with no female factor cause. On the day of ovarian puncture in IVF, follicular fluid and serum were collected from the patients. (3) Results: Malondialdehyde from the follicular fluid was higher in the control group. The total antioxidant capacity in the follicular fluid is positively correlated with the pregnancy rate. There is no statistically significant difference in the oxidative stress markers from serum in both groups. (4) Conclusions: The capacity of the follicular fluid environment to contain the reactive oxygen species (ROS) leads to a higher pregnancy rate in the control group.

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endometriosisinfertility

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