Malignant extraovarian endometriosis: a review

L. Benoit, Benoit L, L. Benoît, Laurent Arnould, L Arnould, Arnould L, N. Cheynel, Cheynel N, Diane B, Boh Fanta Diané, B Diane, S. Causeret, Causeret S, A Machado, Ana Sofia Machado, Machado A, F. Collin, Collin F, Fraisse J, J. Fraisse, Jean Cuisenier, Cuisenier J, J Cuisenier
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2005 · vol. 32(1) , pp. 6–11 · doi:10.1016/j.ejso.2005.08.011 · PMID:16289714 · W2059128284
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This review examines the characteristics, diagnosis, treatment, and prognosis of malignant extraovarian endometriosis, a rare condition that arises outside the ovary.

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Abstract

AIMS: Malignant transformation in extra-ovarian endometriosis is a rare but known complication. This distinct pathological entity is reviewed with a specific focus on aetiology and treatment. METHODS: Studies were identified by searching the English language literature in the MEDLINE database and by an extensive review of bibliographies from articles found through that search. FINDINGS: Up to 1% of women with endometriosis will develop endometriosis-associated neoplasm. Almost a quarter of the reported cases of malignancy in endometriosis have involved extra-ovarian tissues. In many cases, hormonal factors may play a role in its pathogenesis. Estrogen monotherapy in obese patients significantly increase the risk of malignant extra-gonadal endometrial transformation. Genetic anomalies have also been reported such as loss of heterozygosity on chromosome 5q. For patients with disease confined to the site of origin, a 82-100% 5-year survival has been noted for endometrioid cell type; disseminated intraperitoneal disease, however, has a very poor associated prognosis, with a 0-12% 5-year survival overall. CONCLUSIONS: Women with endometriosis-associated cancers most likely represent a different class of patients than traditional ovarian cancer patients and may require different therapeutic options.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Peritoneal Neoplasms Diagnosis, Differential Diagnosis, Differential Endometriosis Endometriosis Endometriosis Female Female Humans Humans Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

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License: CC0 · commercial use OK