Clear cell adenocarcinoma of the urinary bladder: report of a case of probable müllerian origin.

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This report describes a rare case of clear cell adenocarcinoma of the urinary bladder in a 35-year-old woman, with microscopic findings strongly suggesting a müllerian origin from endometriosis.

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Abstract

A 35-yr-old woman with a history of endometriosis and several recent episodes of hematuria was found to have an exophytic tumor arising from the mucosa of the posterior bladder wall. Microscopic examination showed a typical clear cell adenocarcinoma with a predominant tubulo-cystic pattern. A radical cystectomy was performed. Pathologic examination showed no residual tumor, but grossly visible intramural cysts at the site of the tumor had features of endometriosis on microscopic examination, strongly suggesting that the clear cell adenocarcinoma arose from endometriosis and was of müllerian derivation. Only one other adenocarcinoma of the bladder, an endometrioid adenocarcinoma, has had a probable müllerian origin. Although rare, these cases indicate that some vesical adenocarcinomas are of müllerian type.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Cell Transformation, Neoplastic Mullerian Ducts Urinary Bladder Neoplasms Adenocarcinoma Adenocarcinoma Adult Cell Transformation, Neoplastic Endometriosis Endometriosis Endometriosis Female Humans Mullerian Ducts Urinary Bladder Neoplasms Urinary Bladder Neoplasms

Citation neighborhood

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Cited by (9)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:11:39.448046+00:00
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