Endometrioid carcinoma of the urinary bladder complicating vesical Mullerianosis: a case report and review of the literature

Garavan F, F. Garavan, Grainger R, R. Grainger, Jeffers M, Michael Jeffers, M Jeffers
Virchows Archiv : an international journal of pathology · 2004 · vol. 444(6) , pp. 587–9 · doi:10.1007/s00428-004-1010-8 · PMID:15221475 · W2057724937
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This case report describes an endometrioid adenocarcinoma of the urinary bladder arising in vesical Mullerianosis, highlighting diagnostic challenges and the importance of morphology and ancillary studies.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper reports a case of endometrioid adenocarcinoma arising in the urinary bladder in the setting of vesical Mullerianosis, and it reviews the literature on how vesical endometriosis, Mullerianosis, and related malignant transformation can mimic primary bladder neoplasms. The authors describe diagnostic challenges and emphasize the importance of tumor morphology together with ancillary studies to establish the correct diagnosis. A key limitation is that, as a single case report with a literature review, the evidence cannot determine incidence or broader causality. This paper is centrally about endometriosis — it focuses on malignant transformation of vesical endometriosis/Mullerianosis into endometrioid carcinoma of the urinary bladder.

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Abstract

Endometriosis of the urinary bladder is uncommon, and malignant transformation within vesical endometriosis is extremely rare. Vesical endometriosis and Mullerianosis can cause problems in differential diagnosis with vesical neoplasm, and, conversely, primary vesical neoplasm arising in endometriosis can be difficult to distinguish from secondary vesical involvement. Mullerianosis has rarely been described in the urinary bladder. A case of endometrioid adenocarcinoma of the urinary bladder is reported, which illustrates the difficulties in diagnosis and the importance of morphology and ancillary studies in establishing the correct diagnosis.
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Abstract

Endometriosis of the urinary bladder is uncommon, and malignant transformation within vesical endometriosis is extremely rare. Vesical endometriosis and Mullerianosis can cause problems in differential diagnosis with vesical neoplasm, and, conversely, primary vesical neoplasm arising in endometriosis can be difficult to distinguish from secondary vesical involvement. Mullerianosis has rarely been described in the urinary bladder. A case of endometrioid adenocarcinoma of the urinary bladder is reported, which illustrates the difficulties in diagnosis and the importance of morphology and ancillary studies in establishing the correct diagnosis.

References

Arap Neto W, Lopes RN, Cury M, Montelatto NI, Arap S (1984) Vesical endometriosis. Urology 24:271–274 Balat O, Kudelka AP, Edwards CL, Silva E, Kavanagh JJ (1996) Malignant transformation in endometriosis of the urinary bladder: case report of clear cell adenocarcinoma. Eur J Gynaecol Oncol 17:13–16 Bruson G (1988) Malignant extraovarian endometriosis: two case reports and review of the literature. Gynaecol Oncol 30:123–130 Chor PJ, Gaum LD, Young RH (1993) Clear cell adenocarcinoma of the urinary bladder: report of a case of probable Mullerian origin. Mod Pathol 6:225–228 Clement PB, Young RH (1992) Endocervicosis of the urinary bladder. Am J Surg Pathol 16:533–542 Donne C, Vidal M, Buttin X, Becerra P, Carvia R, Zuluaga A, Nogales FF (1998) Mullerianosis of the urinary bladder: clinical and immunohistochemical findings. Histopathology 33:290–292 Kurman RJ (ed) (1994) Blaustein, 4th edn. Pathology of the female genital tract. Chapter 17, Springer, Berlin Heidelberg New York Lichteneld FR (1961) Endometriosis involving the urinary tract, a collective review. Obstet Gynaecol 17:763–768 McCluggage WG, Sumathi VP, Maxwell P (2001) CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology 39:273–278 O’Conor V (1945) Endometriosis of the bladder and ureter. Surg Gynaecol Obstet 80:113–119 Skor AB, Warren MM, Mueller EO Jr (1977) Endometriosis of the urinary bladder. Urology 9:689–692 Sumathi VP, McCluggage WG (2002) CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis. J Clin Pathol 55:391–392 Vara AR, Ruzics EP, Moussabeck O, Martin DC (1990) Endometrioid adenosarcoma of the bladder arising from endometriosis. J Urol 143:813–815 Young RH, Clement PB (1996) Mullerianosis of the urinary bladder. Mod Pathol 9:731–737 Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Garavan, F., Grainger, R. & Jeffers, M. Endometrioid carcinoma of the urinary bladder complicating vesical Mullerianosis: a case report and review of the literature. Virchows Arch 444, 587–589 (2004). https://doi.org/10.1007/s00428-004-1010-8 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00428-004-1010-8

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Endometrioid Endometriosis Mullerian Ducts Urinary Bladder Neoplasms Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometriosis Endometriosis Endometriosis Endometriosis Female Humans Middle Aged Mullerian Ducts Neprilysin Neprilysin Postmenopause

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