Endometriosis is sustained by tumour necrosis factor-alpha
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Tumor necrosis factor-α was found to be essential for sustaining endometriosis in this study.
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Abstract
Endometriosis is a common gynaecological disorder causing pain, infertility, and emotional distress. Evidence presented here suggests that abnormal production of tumour necrosis factor-alpha (TNF-alpha) is required for the establishment and maintenance of endometriosis and also is responsible for the associated infertility through its effect on sperm motility and function and oocyte development. Infliximab, which blocks TNF-alpha function, could be used in the treatment of endometriosis to reverse the above effects.
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Cited by (47)
- The biology and clinical aspects of female infertility 2026
- The biology and clinical aspects of female infertility 2026
- Neuroimmunology of Endometriosis-Associated Pain and Its Psychological Aspects 2024
- Novel Diagnostic Biomarker BST2 Identified by Integrated Transcriptomics Promotes the Development of Endometriosis via the TNF-α/NF-κB Signaling Pathway 2024
- Establishment of Immortalized Human Endometriotic Stromal Cell Line from Ectopic Lesion of a Patient with Endometriosis 2023
- Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies† 2021
- Expression of interleukin 6 and tumor necrosis factor alpha in endometriotic tissues: an immunohistochemical study 2020
- The feasibility of the platelet count and mean platelet volume as markers of endometriosis and adenomyosis: A case control study 2019
- [Role of mast cells in estrogen-mediated experimental endometriosis in rats] 2015
- Effects of Hominis Placenta Pharmacopuncture Therapy on the Experimentally-induced Endometriosis in the Rats 2014
- The diagnostic role of cervico-vaginal fluid interleukins-1α in endometriosis: A case-control study 2014
- Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis 2014
- Possible involvement of signal transducer and activator of transcription-3 in cell-cell interactions of peritoneal macrophages and endometrial stromal cells in human endometriosis 2013
- A tumor necrosis factor-α inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid 2013
- Elevated peritoneal fluid TNF-α incites ovarian early growth response factor 1 expression and downstream protease mediators: a correlation with ovulatory dysfunction in endometriosis 2013
- Anti-TNF-α treatment for pelvic pain associated with endometriosis 2013
- [Endometriosis: aetiopathogenetic basis] 2011
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