Expression of interleukin 6 and tumor necrosis factor alpha in endometriotic tissues: an immunohistochemical study

Nimet FURUCU, Leman Sencar, M. Turan Çetin, İbrahim Ferhat Ürünsak, Derya Gümürdülü, Sait Polat
In: Cukurova Medical Journal · 2020 · vol. 45(3) , pp. 1115–1125 · doi:10.17826/cumj.695962 · W3087890026
article OA: diamond CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This immunohistochemical study found significantly increased expression of TNF-α and IL-6 in epithelial and stromal cells of endometriotic tissues compared to normal endometrium.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This immunohistochemical study compared tissue sections from ectopic endometrium biopsies of 24 women with endometriosis (ages 20–40) to normal endometrium from 10 women without endometrial dysfunction, assessing expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). TNF-α and IL-6 showed weak-to-moderate staining in the epithelial (surface and glandular) compartments but no significant stromal staining in control endometrium. In endometriotic tissues, TNF-α and IL-6 immunoreactivity was significantly increased in epithelial cells, stromal cells, and macrophages, with strong expression in ectopic endometrium, and the paper’s main limitation is that conclusions are based on immunostaining comparisons without mechanistic functional testing. This paper is centrally about endometriosis — it directly measures TNF-α and IL-6 expression patterns in ectopic endometrial tissues.

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Abstract

Purpose: The aim of this study is to investigate Tumor necrosis factor alpha (TNF-α) and Interleukin 6 (IL-6) expressions in normal and endometriotic human tissue using immunohistochemical methods.Materials and Methods: This study examined tissue sections obtained from the tissue biopsies of ectopic endometrium taken from 24 women between the ages of 20 to 40 years. Additionally, the tissue sections taken from the normal endometrium obtained from 10 patients without any endometrial dysfunction due to dilation or curettage were also evaluated, as the control group. Tissue sections prepared by light microscopic and immunohistochemical methods were examined under a light microscope.Results: In the control group TNF-α and IL-6 expressions were identified at varying levels, from weak to moderate, in surface and glandular epithelium; however, there was no evidence of a significant staining in the stromal cells. It is found that TNF-α and IL-6 immunoreactivity in the endometriotic tissues were significantly increased in the epithelial cells, stromal cells and macrophages compared to the control endometrium. Expressions of TNF-α and IL-6 were both strong in the ectopic endometrial tissues. Conclusion: We conclude that TNF-α and IL-6 are important cytokines involved in the pathogenesis of the endometriosis.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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