Inflammation and nerve fiber interaction in endometriotic pain

Brett D McKInnon, Brett McKinnon, Dominic Bertschi, Bertschi D, Nick A. Bersinger, Bersinger NA, Mueller MD, Michael D. Mueller
Trends in endocrinology and metabolism: TEM · 2014 · vol. 26(1) , pp. 1–10 · doi:10.1016/j.tem.2014.10.003 · PMID:25465987 · W2008971863
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This paper investigates the interplay between inflammation and nerve fibers in the context of endometriotic pain.

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Abstract

Endometriosis is an extremely prevalent estrogen-dependent condition characterized by the growth of ectopic endometrial tissue outside the uterine cavity, and is often presented with severe pain. Although the relationship between lesion and pain remains unclear, nerve fibers found in close proximity to endometriotic lesions may be related to pain. Also, women with endometriosis pain develop central sensitization. Endometriosis creates an inflammatory environment and recent research is beginning to elucidate the role of inflammation in stimulating peripheral nerve sensitization. In this review, we discuss endometriosis-associated inflammation, peripheral nerve fibers, and assess their potential mechanism of interaction. We propose that an interaction between lesions and nerve fibers, mediated by inflammation, may be important in endometriosis-associated pain.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Inflammation Nerve Fibers Pelvic Pain Pelvis Cell Communication Cell Communication Disease Progression Disease Progression Endometriosis Endometriosis Endometriosis Estrogens Estrogens Estrogens Female Female Humans Humans Inflammation

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

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License: CC0 · commercial use OK