Angiogenesis and Macrophage Activation in Endometriosis

Robert N. Taylor, Taylor RN, R N Taylor, SABELLE P. RYAN, Ryan IP, I. P. Ryan, ELLEN S. MOORE, Moore ES, E S Moore, Daniela Hornung, Hornung D, D Hornung, J L Shifren, Jan L. Shifren, Shifren JL, Tseng JF, Jennifer F. Tseng, J F Tseng
Annals of the New York Academy of Sciences · 1997 · vol. 828(1) , pp. 194–207 · doi:10.1111/j.1749-6632.1997.tb48540.x · PMID:9329840 · W2093486544
article OA: closed CC0 ⤵ 94 in-corpus citations
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Ectopic endometrial implants recruit capillaries and inflammatory cells by secreting proinflammatory proteins, suggesting a link between endometriosis symptoms, peritoneal inflammation, and cytokine networks.

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Abstract

Recent studies suggest that the symptoms associated with endometriosis are the result of local peritoneal inflammation. Increased concentrations of activated pelvic macrophages and lymphocytes and the elevated levels of specific cytokines and growth factors reviewed above support this hypothesis. The precise roles of these soluble factors are currently unknown, but we propose that a complex network of endometrial cytokines are normally regulated by hormones produced during the ovulatory cycle. Ectopic endometrial implants also are subject to these same endocrine cues. The secretion of these proinflammatory proteins by endometriosis lesions into the peritoneal microenvironment appears to cause a recruitment of capillaries and activated inflammatory cells to the implant. Future therapeutic strategies directed to ameliorate the inflammatory reaction associated with endometriosis should not ignore the likely physiological actions of many of the same bioactive molecules in normal eutopic endometrial function.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Macrophage Activation Macrophages Neovascularization, Pathologic Cells, Cultured Cytokines Cytokines Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Female Humans Macrophages Stromal Cells Stromal Cells

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (60)

Cited by (50)

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