Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin
Lab / animal
OA: bronze
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⤵ 56 in-corpus citations
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This study investigated how interleukin-8 affects endometrial stromal cell adhesion to fibronectin and found that it stimulates this interaction.
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Abstract
OBJECTIVE: To study the effect of interleukin-8 (IL-8) and mouse anti-human IL-8 monoclonal antibody on endometrial stromal cell adhesion to fibronectin.
DESIGN: Prospective, controlled in vitro study.
SETTING: Academic research laboratory.
PATIENT(S): Women undergoing benign gynecologic surgery for indications other than endometrial disease.
INTERVENTION(S): Endometrial stromal cells were treated with IL-8 and mouse anti-human IL-8 monoclonal antibody at different concentrations and adhesion assays were performed by labeling the cells with calcein.
MAIN OUTCOME MEASURE(S): Fluorescence in calcein-labeled endometrial stromal cells.
RESULT(S): IL-8 induced a concentration-dependent increase of cell adhesion to fibronectin matrix (twofold at 10 ng/mL; P = .006). Treatment of endometrial stromal cells with anti-IL-8 neutralizing antibody inhibited partially the cell adhesion.
CONCLUSION(S): IL-8 stimulates the adhesion of endometrial stromal cells to fibronectin in a concentration-dependent manner. IL-8 may thus be relevant for the attachment of endometrial implants in the pathogenesis of endometriosis.
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- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
- Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 do not promote adhesion of human endometrial epithelial cells to mesothelial cells in a quantitative in vitro model 2005
- Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis 2005
- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
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- Increased levels of interleukin-15 in the peritoneal fluid of women with endometriosis: inverse correlation with stage and depth of invasion 2003
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- europepmc
- last seen: 2026-10-17T06:09:56.316927+00:00
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- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
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