Transcriptional characterizations of differences between eutopic and ectopic endometrium

Yan Wu, Wu Y, André Kajdacsy-Balla, Kajdacsy-Balla A, Andre Kajdacsy‐Balla, Estil Strawn, Strawn E, Zainab Basir, Basir Z, Halverson G, Gloria Halverson, Jailwala P, Parthav Jailwala, Yuedong Wang, Wang Y, Wang X, Xujing Wang, Ghosh S, Soumitra Ghosh, Guo SW, Sun-Wei Guo, Sun‐Wei Guo
Endocrinology · 2005 · vol. 147(1) , pp. 232–246 · doi:10.1210/en.2005-0426 · PMID:16195411 · W2032547793
Other OA: bronze CC0 ⤵ 150 in-corpus citations
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This study profiled gene expression in ectopic versus eutopic endometrium from 12 women with endometriosis, identifying 904 differentially expressed genes and 79 associated pathways, including oxidative stress and Wnt signaling.

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Abstract

Endometriosis, defined as the presence of endometrial glandular and stromal cells outside the uterine cavity, is a common gynecological disease with poorly understood pathogenesis. Using laser capture microdissection and a cDNA microarray with 9600 genes/expressed sequence tags (ESTs), we have conducted a comprehensive profiling of gene expression differences between the ectopic and eutopic endometrium taken from 12 women with endometriosis adjusted for menstrual phase and the location of the lesions. With dye-swapping and replicated arrays, we found 904 genes/ESTs that are differentially expressed. We validated the gene expression using real-time RT-PCR. We found that the expression patterns of these genes/ESTs correctly classified the 12 patients into ovarian and nonovarian endometriosis. We identified gene clusters that are location-specific. In addition, we identified several biological themes using Expression Analysis Systematic Explorer. Finally, we identified 79 pathways with over 100 genes with known functions, which include oxidative stress, focal adhesion, Wnt signaling, and MAPK signaling. The identification of these genes and their associated pathways provides new insight. Our findings will stimulate future investigations on molecular genetic mechanisms underlying the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Pregnancy, Ectopic Transcription, Genetic Transcription, Genetic Base Sequence Base Sequence DNA Primers DNA Primers Endometrium Endometrium Expressed Sequence Tags Expressed Sequence Tags Female Female Humans Humans Menstrual Cycle Menstrual Cycle Oligonucleotide Array Sequence Analysis Oligonucleotide Array Sequence Analysis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

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