Endometriosis as a risk factor for age-related macular degeneration: A nationwide population-based study

Jyun-Lin Lee, Jyun‐Lin Lee, Yuan‐Man Hsu, Yu-An Hsu, Yu-Te Huang, Jamie Jiin-Yi Chen, Ming-Yen Wu, Fuu-Jen Tsai, Fuu‐Jen Tsai, Hui-Ju Lin, Yu-Han Huang, Huang Yuhan, Peng-Tai Tien, Peng‐Tai Tien, Lei Wan
Maturitas · 2025 · vol. 195 , pp. 108211 · doi:10.1016/j.maturitas.2025.108211 · PMID:39914136 · W4406981115
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This nationwide population-based study investigated endometriosis as a potential risk factor for age-related macular degeneration, examining the association between the two conditions.

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Abstract

OBJECTIVE: Investigate the association between endometriosis and the incidence of age-related macular degeneration. MATERIAL AND METHODS: This study used data from Taiwan's National Health Insurance Research Database (2000-2018) to examine the link between endometriosis and age-related macular degeneration. The endometriosis cohort included women diagnosed with the condition, with the index date set as their first diagnosis. A control group of women without endometriosis was matched using propensity score matching based on age, year of the index date, and comorbidities. The primary outcome was the occurrence of age-related macular degeneration during the study period. The incidence of age-related macular degeneration was compared between the two cohorts using a Cox regression model, and the risk of developing age-related macular degeneration was estimated with the Kaplan-Meier method. RESULTS: The study included 53,993 individuals per group, with no significant differences in age or comorbidities. The mean follow-up duration was significantly longer for the endometriosis cohort (10.18 years) than the non-endometriosis cohort (9.96 years). Patients with endometriosis exhibited a significantly higher risk of age-related macular degeneration (adjusted hazard ratio = 1.43, 95 % confidence interval: 1.26-1.63, p < 0.001) after adjusting for age and comorbidities. The Kaplan-Meier curves confirmed an increased cumulative incidence of age-related macular degeneration in the endometriosis cohort. Subgroup analysis revealed a higher risk of age-related macular degeneration in patients with endometriosis across various age groups and in those without comorbidities. CONCLUSION: This study demonstrated a significant association between endometriosis and the risk of developing age-related macular degeneration in women.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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