Measurable serum markers of oxidative stress response in women with endometriosis

Ιrene Lambrinoudaki, Irene V Lambrinoudaki, Augoulea A, Areti Augoulea, Christodoulakos GE, George Christodoulakos, George E Christodoulakos, Emmanuel V Economou, Economou EV, Emmanuel Economou, George Kaparos, Kaparos G, A. Kontoravdis, Kontoravdis A, Antonios Kontoravdis, Constantinos B. Papadias, Papadias C, Constantinos Papadias, Creatsas G, George Creatsas
Fertility and sterility · 2008 · vol. 91(1) , pp. 46–50 · doi:10.1016/j.fertnstert.2007.11.021 · PMID:18206876 · W2086090458
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This study investigated serum markers of oxidative stress response in women with endometriosis to identify potential diagnostic indicators.

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Abstract

OBJECTIVE: To evaluate the hypothesis of increased systemic oxidative stress in patients with endometriosis. SETTING: Tertiary care university hospital. DESIGN: Cross-sectional study. PATIENT(S): Sixty-six women of reproductive age undergoing laparoscopy. INTERVENTION(S): All women were investigated for endometriotic foci during laparoscopy. Forty-five women had laparoscopically and histologically confirmed endometriosis, and 21 women did not have endometriosis. MAIN OUTCOME MEASURE(S): Four markers of oxidative stress were assessed in the serum of each patient: heat shock protein 70 (HSP70), HSP70b', thioredoxin (TRX), and ischemia-modified albumin (IMA). RESULT(S): Mean serum HSP 70b' level was higher in patients with endometriosis compared with controls (0.178 ng/mL, SD 0.103, and 0.135 ng/mL, SD 0.014, respectively). The disease stage did not affect HSP70b' levels. Heat shock protein 70, IMA, and TRX levels did not differ between patients with endometriosis and controls. Women with a history of arterial hypertension had higher mean IMA levels compared with women with normal blood pressure independently of the presence of endometriosis (106.7 [SD 25.4] U/mL and 85.0 [SD 11.5] U/mL, respectively). CONCLUSION(S): Endometriosis is associated with increased systemic oxidative stress. The implication of increased systemic oxidative stress in disease progression or the association with other oxidative stress-related pathologic conditions needs to be addressed in further studies.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Endometriosis HSP70 Heat-Shock Proteins Oxidative Stress Oxidative Stress Serum Albumin Thioredoxins Adult Adult Biomarkers Biomarkers Endometriosis Endometriosis Endometriosis Female Female HSP70 Heat-Shock Proteins HSP70 Heat-Shock Proteins Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (44)

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