Effect of Goserlin Acetate and Oxidative Stress in Iraqi Women with Recurrenceof Endometriosis

Tamara Sami Naji, Salwa H. N. Al- Rubae'i, Kisma M. Turki
In: IOSR Journal of Dental and Medical Sciences · 2016 · vol. 15(07) , pp. 117–122 · doi:10.9790/0853-15073117122 · W2493618029
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Goserlin acetate treatment in women with recurrent endometriosis altered hormone levels, decreased antioxidant status, and increased oxidative stress compared to healthy controls.

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Abstract

Although surgery is currently the treatment of choice for managing endometriosis, recurrence poses a formidable challenge. Goserlinacetateis one of the most widely used medical therapies of endometriosisto induce ovarian suppression. The aim of this study was to evaluate the effect of goserlin acetate treatment on the hormonal changes (Luteinizing Hormone (LH), Follicle Stimulating Hormones (FSH), Testosterone (Test.) and Estradiol (E 2 )),antioxidant status (A, E, -carotene and C) vitamins, Coenzyme Q 10 (CoQ 10 ), uric acid (UA) and oxidative stress (MDA) in goserelintreated patients with endometriosis.Ninety women were participated in this study.Sixty women patients with endometriosiswere undergoing laparoscopy and treated with goserlin acetate included as patients group (G1), age range was between 25-46 years. Thirty healthy women were selected as the control group (G2) age range was between 23-45 years.Results revealed that there is the highly significant difference (P0.01) between G1 and G2 groups in sera (Test., E 2 , -carotene, vitamin C, CoQ 10 , UA and MDA) levels. The results showed a significant higher (p<0.05) BMI, W/H and LH/FSHand lower level of vitamin A in recurrent endometriosis in comparing with control group. Correlations studies indicated a significant correlation between Test. hormone and MDA levels in G1. The results of this study concluded that there is a significant and very effective role of goserlin acetate in alteration of the hormones changes and antioxidants status of women patients with endometriosis after the period of treatment. The relationship between the variables that increase in the Test. levels at the same time E 2 levels displayed highly significant depletion in G1 patients compared with G2.The effect of goserlin acetate by increasing the levels of oxidative stress and decreasing levels of antioxidant status. It is considered one of the most side effects of this treatment and prefers to choose other types of hormonal treatment to get a better result.

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endometriosis

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