The pathophysiology of uterine adenomyosis: an update

Benagiano G, Giuseppe Benagiano, Habiba M, Marwan Habiba, Brosens I, Ivo Brosens
Fertility and sterility · 2012 · vol. 98(3) , pp. 572–579 · doi:10.1016/j.fertnstert.2012.06.044 · PMID:22819188 · W1969979700
Review OA: closed CC0 ⤵ 135 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This review provides an updated overview of the current understanding of uterine adenomyosis pathophysiology, covering key aspects of its development and progression.

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Abstract

The diagnosis of adenomyosis using noninvasive techniques such as vaginal ultrasounds and magnetic resonance has clear clinical applications and has renewed the interest in the pathogenesis of uterine adenomyosis. However, the research remains hampered by the lack of consensus on the classification of lesions. Magnetic resonance imaging and transvaginal ultrasound have comparable diagnostic accuracy. Minimal interventional biopsy techniques have recently been introduced. This article reviews human and animal studies and provides an update on the pathophysiology of adenomyosis. Recent views on the pathogenesis and links with endometriosis are discussed.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Uterine Diseases Animals Animals Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Neovascularization, Physiologic Neovascularization, Physiologic Uterine Diseases Uterine Diseases Uterine Diseases Uterine Diseases Uterine Diseases

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (50)

Source provenance

europepmc
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License: CC0 · commercial use OK