Pathogenetic significance of increased levels of interleukin-8 in the peritoneal fluid of patients with endometriosis

T Iwabe, Iwabe T, Tomio Iwabe, T Harada, Harada T, Tasuku Harada, Tsudo T, Toshiyuki Tsudo, T Tsudo, Masahiro Tanikawa, Tanikawa M, M Tanikawa, Yoshimasa Onohara, Onohara Y, Y Onohara, N Terakawa, Naoki Terakawa, Terakawa N
Fertility and sterility · 1998 · vol. 69(5) , pp. 924–930 · doi:10.1016/s0015-0282(98)00049-1 · PMID:9591504 · W1978598833
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This study investigated the role of elevated interleukin-8 in the peritoneal fluid of endometriosis patients, examining its pathogenetic significance.

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Abstract

OBJECTIVE: To investigate the role of interleukin-8 (IL-8) in peritoneal fluid of patients with endometriosis in the pathogenesis of endometriosis. DESIGN: Peritoneal fluid was collected by laparoscopy. Endometrial and endometriotic stromal cells were obtained from normal endometrium and from chocolate cyst linings of the ovary. SETTING: Department of Obstetrics and Gynecology of Tottori University Hospital, Yonago, Japan. PATIENT(S): Forty women who underwent either laparoscopy or laparoscopic surgery. MAIN OUTCOME MEASURE(S): The peritoneal fluid concentration of IL-8 was analyzed by enzyme-linked immunosorbent assay, and the correlation between the IL-8 concentration and the extent of active endometriosis was investigated. The effect of IL-8 on cell proliferation was examined by tetrazolium bromide and thymidine incorporation. The expression of IL-8 receptor was examined in stromal cells by reverse transcription polymerase chain reaction. RESULT(S): The level of IL-8 in peritoneal fluid was significantly higher in patients with endometriosis than in patients without endometriosis. A significant correlation was noted with the extent of active endometriosis. Interleukin-8 significantly increased the number of cells and DNA synthesis in the endometrial and endometriotic stromal cells in a dose-dependent manner. Transcripts of IL-8 receptor type A were detected in stromal cells. CONCLUSION(S): The present study suggests that IL-8 found in the peritoneal fluid of patients with endometriosis contributes to the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-8 Antigens, CD Antigens, CD Antigens, CD Ascitic Fluid Ascitic Fluid Cell Division Cell Division Cells, Cultured Cells, Cultured Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

Cited by (50)

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