Targeted inhibition of TAK1 abrogates TGFβ1 non-canonical signaling axis, NFκB/Smad7 inhibiting human endometriotic cells proliferation and inducing cell death involving autophagy

Jyoti B Kaushal, Jyoti Kaushal, Vinay Shukla, Pushplata Sankhwar, Rajesh K Jha, Rajesh Kumar Jha, Anila Dwivedi
Cytokine · 2021 · vol. 148 , pp. 155700 · doi:10.1016/j.cyto.2021.155700 · PMID:34560609 · W3199209690
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Targeted inhibition of TAK1 abrogated TGFβ1 non-canonical signaling, suppressed NFκB/Smad7, and reduced human endometriotic cell proliferation while inducing autophagy-involved cell death.

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Condition tags

endometriosis

MeSH descriptors

Autophagy Autophagy Endometriosis Endometriosis MAP Kinase Kinase Kinases NF-kappa B Signal Transduction Signal Transduction Smad7 Protein Transforming Growth Factor beta1 Apoptosis Apoptosis Cell Cycle Checkpoints Cell Cycle Checkpoints Cell Death Cell Death Cell Line Cell Proliferation Cell Proliferation Cells, Cultured

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europepmc
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openalex
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