Effect of endometriosis on in vitro fertilization

Barnhart K, Kurt T. Barnhart, Kurt Barnhart, Dunsmoor-Su R, Rebecca Dunsmoor-Su, Christos Coutifaris, Coutifaris C
Fertility and sterility · 2002 · vol. 77(6) , pp. 1148–1155 · doi:10.1016/s0015-0282(02)03112-6 · PMID:12057720 · W2048198010
Systematic review / meta-analysis OA: closed CC0 ⤵ 623 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper investigated the impact of endometriosis on in vitro fertilization outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To investigate the IVF outcome for patients with endometriosis. DESIGN: Meta-analysis. SETTING: Academic research center. PATIENT(S): A MEDLINE search and review of the literature were performed. Patients were classified by level of endometriosis, and controls were classified according to the indication for IVF. INTERVENTION(S): Bivariate analysis and multivariate logistic regression was used to estimate overall effect and control for confounding. MAIN OUTCOME MEASURE(S): Pregnancy rates, fertilization rate, implantation rates, and numbers of oocytes retrieved. RESULT(S): Twenty-two published studies were included in the overall analysis. The chance of achieving pregnancy was significantly lower for endometriosis patients (odds ratio, 0.56; 95% confidence interval, 0.44-0.70) when compared with tubal factor controls. Multivariate analysis also demonstrated a decrease in fertilization and implantation rates, and a significant decrease in the number of oocytes retrieved for endometriosis patients. Pregnancy rates for women with severe endometriosis were significantly lower than for women with mild disease (odds ratio, 0.60; 95% confidence interval, 0.42-0.87). CONCLUSION(S): Patients with endometriosis-associated infertility undergoing IVF respond with significantly decreased levels of all markers of reproductive process, resulting in a pregnancy rate that is almost one half that of women with other indications for IVF. These data suggest that the effect of endometriosis is not exclusively on the receptivity of the endometrium but also on the development of the oocyte and embryo.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertilization in Vitro Fertilization in Vitro Adult Adult Cell Count Cell Count Embryo Implantation Embryo Implantation Endometriosis Endometriosis Female Female Fertilization Fertilization Humans Humans Oocytes Oocytes Oocytes

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (88)

Cited by (50)

Source provenance

crossref
last seen: 2026-05-17T01:00:03.831243+00:00
europepmc
last seen: 2026-10-15T06:08:49.021275+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:00:31.392641+00:00
unpaywall
last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0 · commercial use OK