Kurt T. Barnhart

OBJECTIVE: To determine the future priorities for ectopic pregnancy research. DESIGN: Potential research questions were collated from an initial international survey, a systematic review of clinical practice guidelines, and Cochrane system…

OBJECTIVE: To evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared with controls, and assess their association with the disease. DESIGN: Retrospective…

Endometriosis is a chronic, complex disease for which there are vast disparities in diagnosis and treatment between sociodemographic groups. Clinical presentation of endometriosis can vary from asymptomatic disease-often identified during (…

ObjectivesTo describe ovulation inhibition and safety of daily oral ulipristal acetate (UPA) over 84 days.Study designThis multi-center phase 1 and/or 2 trial randomized participants to use oral ulipristal 10 mg or 5 mg daily or a 3 cycle r…

OBJECTIVE: To determine if coexisting adenomyosis limits the efficacy of elagolix, an oral gonadotropin-releasing hormone antagonist, with hormonal add-back therapy in reducing heavy menstrual bleeding in women with uterine fibroids. DESIGN…

ObjectiveEndometriosis is a chronic, estrogen dependent condition that affects 5-10% of reproductive aged women and is associated with pelvic pain and infertility. As the approach to therapy shifts from surgical ablation to pharmacological …

OBJECTIVE: To assess the impact of endometriosis, alone or in combination with other infertility diagnoses, on IVF outcomes. DESIGN: Population-based retrospective cohort study of cycles from the Society for Assisted Reproductive Technolog…

A biomarker can be used for early diagnosis of a disease, identification of individuals for disease prevention, as a potential drug target, or as a potential marker for a drug response. A biomarker may also limit the use of drug (and theref…

There is a great need for biomarkers that can serve as surrogates for important clinical endpoints such as endometriosis. The pursuit of a marker has been hampered by disparate study designs, small samples, and controversy regarding desired…

OBJECTIVE: To identify potential novel biomarkers that differ between subjects with and without endometriosis and that might aid in developing a noninvasive, serum-based diagnostic test. DESIGN: Case-control evaluation of a diagnostic test…

The objective of this case-control study of 242 reproductive-age women was to determine the concentration of afamin in the serum and peritoneal fluid of women with and without endometriosis and to test afamin as a diagnostic marker of endom…

Based on a recent review of the medical literature, a clinical diagnosis of infertility may not agree with strict criteria. Standardized definitions of diagnostic categories are essential for accurate patient prognosis and future research.

OBJECTIVE: To evaluate whether a combination of putative markers of inflammation and CA-125 could serve as a multiple-marker screening test for endometriosis in a heterogeneous population of patients. DESIGN: Case-control evaluation of a d…

Because imaging methods are unreliable for diagnosing or staging endometriosis, a definitive diagnosis requires surgery. The fact that the disease produces a local, and probably also a systemic, inflammatory process raises the possibility t…

OBJECTIVE: To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis. METHOD: Nine subjects underwent two…

ObjectiveTo investigate the IVF outcome for patients with endometriosis.DesignMeta-analysis.SettingAcademic research center.Patient(s)A MEDLINE search and review of the literature were performed. Patients were classified by level of endomet…

The oral contraceptive pill is one of the most extensively studied medications ever prescribed. The health benefits are numerous and outweigh the risks of their use. Definitive evidence exists for protection against ovarian and endometrial …