Intraovarian steroidogenesis in women with endometriosis undergoing IVF

Galati G, Giulia Galati, Marco Reschini, Reschini M, Maíra Casalechi, Casalechi M, Elisa Polledri, Polledri E, Di Stefano G, Giorgia Di Stefano, Fustinoni S, Silvia Fustinoni, Lombardo F, Francesco LOMBARDO, Ludovico Muzii, Muzii L, Paola Vigano’, Paola Vigano, Vigano P, Edgardo Somigliana, Somigliana E
Reproductive BioMedicine Online · 2026 · vol. 53(5) , pp. 105882 · doi:10.1016/j.rbmo.2026.105882 · PMID:42603467 · W7169885422
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-31 ⓘ

This study investigated the steroidogenic profiles within ovarian follicles of women with endometriosis undergoing in vitro fertilization.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

RESEARCH QUESTION: Is endometriosis associated with alterations in the intraovarian steroidogenic milieu in women undergoing IVF compared with rigorously matched women without the disease? DESIGN: Prospective cohort study comparing intrafollicular steroid hormone concentrations between women with and without endometriosis undergoing IVF. Eighty-three affected women were recruited and matched 1:1 with controls for age at oocyte retrieval, study period, stimulation regimen and serum anti-Müllerian hormone. Follicular fluid was collected, pooled and stored. Concentrations of 14 steroid hormones were measured using liquid chromatography-tandem mass spectrometry. Subgroup analyses focused on women with ovarian endometriomas and on intra-patient comparisons in cases of unilateral disease. RESULTS: Compared with controls, women with endometriosis showed significantly higher concentrations of 11-deoxycortisol and lower concentrations of aldosterone and progesterone (adjusted P = 0.024 for all). These differences were more pronounced in women with ovarian endometriomas, who also had significantly higher concentrations of corticosterone, dehydroepiandrosterone and testosterone than controls (adjusted P = 0.003, P = 0.011 and P = 0.003, respectively). No significant differences in steroid concentrations were observed between affected and contralateral intact ovaries in women with unilateral endometriomas. CONCLUSIONS: The follicular fluid of women with endometriosis has a distinct hormonal profile compared with that of controls, suggesting alterations in steroidogenesis. Reasons explaining these differences, as well as their clinical relevance, remain unknown and deserve further investigations.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

SciLite annotations

chemicals 9
steroid steroid hormone 11-deoxycortisol aldosterone progesterone corticosterone dehydroepiandrosterone testosterone steroid

Source provenance

europepmc
last seen: 2026-08-27T06:11:05.884134+00:00
openalex
last seen: 2026-08-27T06:01:51.984654+00:00
pubmed
last seen: 2026-08-27T06:03:44.756312+00:00
scilite
last seen: 2026-08-23T10:03:07.687773+00:00
unpaywall
last seen: 2026-08-27T06:26:25.619941+00:00
License: CC0 · commercial use OK