IVF Stimulation Protocols and Outcomes in Women with Endometriosis

Endometriosis is a complex disease by itself. When considering fertility, corrective surgeries may compromise the outcome of these women. Different protocols with varying success rates have been evaluated. The long-standing debate between the long protocols, which offers the benefits of a prolonged suppression of the pituitary, or the antagonist protocols, which are shorter and have the added safety benefit, is slowly addressing to the antagonists. The great advances observed with vitrification techniques have led to the use of newer methods of ovarian stimulation (OS) like the progesterone primed only (PPOS) protocol which offers the safety benefit while also being cheaper with better patient compliance. No protocol has been proved to be superior to the others. Early intervention with in vitro fertilization, irrespective of the protocol, can give these women early and good results. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

Hodgson RM, Lee HL, Wang R, Mol BW, Johnson N. Interventions for endometriosis-related infertility: a systematic review and network meta-analysis. Fertil Steril. 2020;113:374–382.e2. Practice Committee of the American Society for reproductive Medicine T. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012;98:591–8. Younis JS, Shapso N, Fleming R, Ben-Shlomo I, Izhaki I. Impact of unilateral versus bilateral ovarian endometriotic cystectomy on ovarian reserve: a systematic review and meta-analysis. Hum Reprod Update. 2019;25:375–91. Parikh FR, Athalye AS, Naik NJ, Naik DJ, Sanap RR, Madon PF. Preimplantation genetic testing: its evolution, where are we today? J Hum Reprod Sci. 2018;11:306–14. Rodriguez-Purata J, Coroleu B, Tur R, Carrasco B, Rodriguez I, Barri PN. Endometriosis and IVF: are agonists really better? Analysis of 1180 cycles with the propensity score matching. Gynecol Endocrinol. 2013;29:859–62. de Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet. 2010;376:730–8. Ferrero S, Gillott DJ, Remorgida V, Anserini P, Ragni N, Grudzinskas JG. GnRH analogue remarkably down-regulates inflammatory proteins in peritoneal fluid proteome of women with endometriosis. J Reprod Med. 2009;54:223–31. Sallam HN, Garcia-Velasco JA, Dias S, Arici A, Abou-Setta AM, Jaafar SH. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev. 2006;2021:CD004635. Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2019;25:592–632. Garcia-Fernandez J, García-Velasco JA. Endometriosis and reproduction: what we have learned. Yale J Biol Med. 2020;93:571–7. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril. 2002;77:1148–55. Garcia-Velasco JA, Arici A. Is the endometrium or oocyte/embryo affected in endometriosis? Hum Reprod. 1999;14:77–89. Boucret L, Bouet P-E, Riou J, Legendre G, Delbos L, El HH, et al. Endometriosis lowers the cumulative live birth rates in IVF by decreasing the number of embryos but not their quality. J Clin Med. 2020;9:2478. Ferrero H, Corachan A, Aguilar A, Quiñonero A, Carbajo-Garcia MC, Alama P, et al. Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality. Hum Reprod. 2019;34:1302–12. Omland AK, Fedorcsák P, Storeng R, Dale PO, Åbyholm T, Tanbo T. Natural cycle IVF in unexplained, endometriosis-associated and tubal factor infertility. Hum Reprod. 2001;16:2587–92. Anon. Handbook of In Vitro Fertilization. 4th ed. Boca Raton: CRC Press; 2017. Pabuccu R, Onalan G, Kaya C. GnRH agonist and antagonist protocols for stage I-II endometriosis and endometrioma in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2007;88:832–9. Drakopoulos P, Rosetti J, Pluchino N, Blockeel C, Santos-Ribeiro S, de Brucker M, et al. Does the type of GnRH analogue used, affect live birth rates in women with endometriosis undergoing IVF/ICSI treatment, according to the rAFS stage? Gynecol Endocrinol. 2018;34:884–9. Zhao F, Lan Y, Chen T, Xin Z, Liang Y, Li Y, et al. Live birth rate comparison of three controlled ovarian stimulation protocols for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve after endometrioma cystectomy: a retrospective study. J Ovarian Res. 2020;13:23. Cao X, Chang HY, Xu JY, Zheng Y, Xiang YG, Xiao B, et al. The effectiveness of different down-regulating protocols on in vitro fertilization-embryo transfer in endometriosis: a meta-analysis. Reprod Biol Endocrinol. 2020;18:16. Mathieu D’Argent E, Ferrier C, Zacharopoulou C, Ahdad-Yata N, Boudy AS, Cantalloube A, et al. Outcomes of fertility preservation in women with endometriosis: comparison of progestin-primed ovarian stimulation versus antagonist protocols. J Ovarian Res. 2020;13:18. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Banker, J., D’Allagnol, H., Garcia-Velasco, J.A. (2024). IVF Stimulation Protocols and Outcomes in Women with Endometriosis. In: Ferrero, S. (eds) Endometriosis-related Infertility. Springer, Cham. https://doi.org/10.1007/978-3-031-50662-8_15 Download citation DOI: https://doi.org/10.1007/978-3-031-50662-8_15 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-50661-1 Online ISBN: 978-3-031-50662-8 eBook Packages: MedicineMedicine (R0)