Danazol Inhibits Steroidogenesis
Lab / animal
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CC0
⤵ 89 in-corpus citations
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This paper investigates the inhibitory effects of danazol on steroidogenesis.
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Abstract
Danazol was found to inhibit multiple enzymes of steroidogenesis directly in the pregnant mare serum (PMS)-treated hamster ovary and the rat testis and adrenal in vitro. In the PMS-treated hamster ovary, danazol inhibited 17alpha-hydroxylase, 17,20-lyase, and 3beta-hydroxysteroid dehydrogenase. In the rat testis, danazol inhibited 17alpha-hydroxylase, 17,20-lyase, 3beta-hydroxysteroid dehydrogenase, and 17beta-hydroxysteroid dehydrogenase. In the rat adrenal, danazol inhibited 3beta-hydroxysteroid dehydrogenase, 21-hydroxylase, and 11beta-hydroxylase. Two hours after a subcutaneous injection of 5 mg/kg of danazol to adult male rats, serum luteinizing hormone levels were significantly increased and serum testosterone levels were significantly suppressed. These findings suggest that in the rodent one of danazol's major pharmacologic effects is the direct inhibition of steroidogenesis.
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Cited by (50)
- Treatment of endometriosis associated with infertility 2010
- Effects of Danazol on the epididymal function in male langurs (Presbytis entellus entellus Dufresne) 2009
- Reversible inhibition of spermatogenesis by danazol with combination of testosterone enanthate in rabbit 2009
- Danazol for pelvic pain associated with endometriosis 2007
- Modern Medical Therapy of Endometriosis 2004
- Treatment of endometrial hyperplasia with a danazol-releasing intrauterine device: a prospective study 2004
- Hemodynamic effect of danazol therapy in women with uterine leiomyomata 2003
- A benefit-risk assessment of medical treatment for uterine leiomyomas 2002
- Danazol for pelvic pain associated with endometriosis 2001
- Treatment of endometriosis 2001
- Estudo Morfológico e Morfométrico da Mama de Ratas em Estro Permanente, Tratadas com Danazol 2001
- Endometriosis and Pelvic Pain 1998
- Endometriosis. Laparoscopy--diagnostic and therapeutic approaches 1997
- Danazol concentrations in ovary, uterus, and serum and their effect on the hypothalamic-pituitary-ovarian axis during vaginal administration of a danazol suppository 1995
- Leukocyte subpopulation changes in rats with autotransplanted endometrium and the effect of danazol 1995
- Endometriosis 1993
- Endometriosis 1993
- Evidence for estrogen synthesis in adenomyotic tissues 1993
- The effects of fetal exposure to danazol 1992
- Endometriosis Associated with Infertility: Therapeutic Approaches 1992
- The use of danazol as a treatment of endometriosis 1991
- Pseudomenopause treatment for endometriosis: The endocrine effects of danazol compared with the use of the LH-RH agonist goserelin 1991
- The effect of danazol on pulsatile gonadotropin secretion in women with endometriosis 1991
- Endometriosis 1990. Current treatment approaches 1990
- Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate 1990
- Comparison of the pharmacology of nafarelin and danazol 1990
- The effect of danazol and the LHRH agonist analogue goserelin (Zoladex) on the biological activity of luteinizing hormone in women with endometriosis 1990
- Inhibition of rat ovarian 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17 alpha-hydroxylase and 17,20 lyase by progestins and danazol 1989
- New therapy for endometriosis 1988
- Plasma and peritoneal fluid levels of CA 125 in women with endometriosis 1988
- The treatment of symptomatic benign breast disease with danazol 1988
- Immunosuppressive effects of danazol in vitro 1987
- Endometriosis 1987
- Danazol treatment of advanced prostate cancer: clinical and hormonal effects 1986
- Relationship of gonadotropin-releasing hormone, danazol, and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit 1986
- Cytoplasmic and nuclear estrogen binding capacity in the rat uterus during treatment with danazol and testosterone 1986
- Effects of danazol on steroidogenesis and gonadotropic responsiveness in isolated human preovulatory follicular cells 1986
- Testis functions and sexual potentia in langur monkey treated with a combination steroidal contraceptive formulation 1986
- Direct biphasic effects of danazol on gonadotropin-dependent differentiation of cultured rat granulosa cells 1986
- Effects of danazol on spermatogenesis in adult rats 1986
- Inhibition of gonadotropin-releasing hormone receptors in rat anterior pituitary monolayer cell cultures by danazol 1986
- Danazol and fetal masculinization: a warning 1985
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1985
- Changes in the biochemical composition of semen following danazol plus testosterone enanthate administration to the langur monkey 1985
- Gynecologic Problems of Adolescence 1985
- Conservative treatment of endometriosis externa: the effects of danazol therapy 1985
- Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up 1985
- Short-term effects of danazol on endometrial histology 1984
- Endometriosis 1984
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1984
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