Pseudomenopause treatment for endometriosis: The endocrine effects of danazol compared with the use of the LH-RH agonist goserelin

P. Maouris, Mitch Dowsett, Janet E. Nichol, Gillian Rose, D. Keith Edmonds
In: Journal of Obstetrics and Gynaecology · 1991 · vol. 11(2) , pp. 123–127 · doi:10.3109/01443619109013535 · W2085043864
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Goserelin achieved hypogonadotropic hypoestrogenism comparable to ovarian ablation, while danazol caused less estrogen suppression but significantly reduced sex hormone-binding globulin in women with endometriosis.

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Abstract

SummaryThe endocrine effects of danazol and goserelin were studied in 10 and 20 women with endometriosis, respectively. Goserelin caused a profound degree of hypogona-dotrophic hypo-oestrogenism comparable with complete ovarian ablation. Danazol caused a less pronounced hypo-oestrogenism but in addition caused a dramatic decrease in sex hormone binding globulin. The implications of this on the mechanism of action of danazol and its clinical side effects are discussed.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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