Pseudomenopause treatment for endometriosis: The endocrine effects of danazol compared with the use of the LH-RH agonist goserelin

P Maouris, Mitch Dowsett, Janet E. Nichol, Gillian Rose, D. Keith Edmonds
In: Journal of Obstetrics and Gynaecology · 1991 · vol. 11(2) , pp. 123–127 · doi:10.3109/01443619109013535 · W2085043864
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Goserelin achieved hypogonadotropic hypoestrogenism comparable to ovarian ablation, while danazol caused less estrogen suppression but significantly reduced sex hormone-binding globulin in women with endometriosis.

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Abstract

SummaryThe endocrine effects of danazol and goserelin were studied in 10 and 20 women with endometriosis, respectively. Goserelin caused a profound degree of hypogona-dotrophic hypo-oestrogenism comparable with complete ovarian ablation. Danazol caused a less pronounced hypo-oestrogenism but in addition caused a dramatic decrease in sex hormone binding globulin. The implications of this on the mechanism of action of danazol and its clinical side effects are discussed.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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