Effects of Danazol on spermatogenesis in adult rats

Marinus J. van Kroonenburgh, J. L. M. Beck, H.M. Vemer, Chris M.G. Thomas, R. Rolland, C. J. Herman
In: Reproduction · 1986 · vol. 77(1) , pp. 233–238 · doi:10.1530/jrf.0.0770233 · PMID:3088269 · W2034196474
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Danazol treatment in adult rats suppressed serum testosterone and FSH/LH, decreased testis weight, and inhibited spermatogenesis after the primary spermatocyte stage, but did not alter spermatogonia numbers.

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Abstract

Adult male Wistar rats were treated with Danazol (4 mg/day s.c.) for 52 days. The drug produced a marked, rapid drop in serum testosterone concentrations to very low levels and caused a slower decrease in serum FSH, LH and testis weight. Flow cytometric analysis of testicular cell suspensions showed a decline in the absolute numbers of haploid cells (spermatids), tetraploid cells (mainly pachytene spermatocytes) and of cells in the S-phase of the division cycle, suggesting that Danazol inhibited proliferation of spermatogonia and/or primary spermatocytes. Histological counting of the different types of spermatogonia, however, revealed no significant change in their numbers during Danazol treatment. It is concluded that Danazol inhibited spermatogenesis primarily after the preleptotene stage of primary spermatocytes.

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